Valmary Séverine, Seulin Patrick, Lamant-Rochaix Laurence, Pradère Bernard, Selves Janick
Service d'anatomie et cytologie pathologiques, Hôpital Purpan, Toulouse.
Ann Pathol. 2003 Jun;23(3):240-3.
We report the case of a 53-year-old man who presented a mass involving the head of the pancreas resulting in isolated jaundice. Histologically, the tumor was an undifferentiated carcinoma with osteoclast-like giant cells of the pancreas. This very rare neoplasm resembles giant cell tumor of bone. An epithelial origin is now established and this tumor has been recently considered as a variant of ductal adenocarcinoma of the pancreas in the last WHO histological classification. The diagnosis requires both morphology and immunohistochemistry. Although the prognosis of these tumors is reported to be poor, our case is unusual because of a favorable outcome without relapse after 2 years.
我们报告了一例53岁男性病例，该患者出现了一个累及胰头的肿块，导致单纯性黄疸。组织学上，肿瘤为胰腺未分化癌伴破骨细胞样巨细胞。这种非常罕见的肿瘤类似于骨巨细胞瘤。目前已确定其起源于上皮，在最新的世界卫生组织组织学分类中，该肿瘤最近被认为是胰腺导管腺癌的一种变体。诊断需要结合形态学和免疫组织化学检查。尽管据报道这些肿瘤的预后较差，但我们的病例不同寻常，因为患者在两年后预后良好且未复发。
