Moskalenko Iu E, Demchenko I T, Krivchenko A I, Burov S V, Deriĭ A N
Fiziol Zh SSSR Im I M Sechenova. 1975 Oct;61(10):1486-92.
rCBF under normal conditions in the rabbit, cat, and monkey brain was found to have a spontaneous periodicity while rCBF responses to afferent flicker stimulation usually revealed a double-phasic fluctuative pattern. This suggests that the rCBF regulatory system consists of not less than two regulatory chains with different time constants, and a feedback. The data on cerebral vascular responses to microapplication of mCSF solutions with various pH, potassium and catecholamines concentrations, suggest that rapid regulatory chains may be conditioned by potassium and neurogenic vascular effects, while slow ones could be mediated by CO2 and related pH changes.
研究发现，在正常情况下，兔、猫和猴脑的局部脑血流量（rCBF）具有自发周期性，而rCBF对传入闪烁刺激的反应通常呈现双相波动模式。这表明rCBF调节系统由不少于两条具有不同时间常数的调节链和一个反馈组成。关于脑血管对微注射不同pH值、钾离子和儿茶酚胺浓度的脑脊液（mCSF）溶液的反应数据表明，快速调节链可能由钾离子和神经源性血管效应决定，而缓慢调节链可能由二氧化碳及相关pH值变化介导。
