Montané J, Marco I, López-Olvera J, Perpiñán D, Manteca X, Lavín S
Servei d'Ecopatologia de Fauna Salvatge, Facultat de Veterinaria, Universitat Autònoma de Barcelona, 08193-Bellaterra, Barcelona, Spain.
J Wildl Dis. 2003 Apr;39(2):375-86. doi: 10.7589/0090-3558-39.2.375.
The aim of this study was to evaluate effect of a short-acting neuroleptic (acepromazine) on capture stress response in roe deer (Capreolus capreolus). Sixteen roe deer were captured by drive-nets in the winters of 1998, 1999, and 2001. Roe deer were divided into two groups: animals in the treatment group received an intramuscular injection of acepromazine (0.093 mg/kg +/- 0.003 SEM; n = 8) while animals in the control group (n = 8) did not receive tranquilizer. Heart rate and body temperature, as well as hematologic and biochemical indicators of stress, were used to evaluate effect of the neuroleptic over 3 hr. Heart rate decreased over time after capture in both groups (P < 0.05), but stabilized sooner in the treated roe deer (75 min after capture) than in the controls (105 min after capture). Body temperature decreased over 45 min and then stabilized in both groups (P < 0.05). Comparisons of blood parameters revealed significantly lower red blood cell count (RBC), lymphocyte count, hemoglobin concentration, packed cell volume (PCV), and serum alanine aminotransferase (ALT), aspartate aminotransferase (AST), creatine kinase (CK), and lactate dehydrogenase (LDH) activities in tranquilized animals compared with controls (at least P < 0.05). A reduction in PCV, lymphocyte count, and serum cortisol concentrations (at least P < 0.05) and an increase in serum creatinine levels (P < 0.05) were recorded over time in control animals, while a reduction in RBC and hemoglobin concentration (at least P < 0.05) and an increase in serum urea concentrations (P < 0.05) over time were observed in the treated group. Finally, a decrease in serum lactate and potassium levels and an increase in CK, AST, ALT, and LDH activities were recorded over time in both groups. Results obtained showed the suitability of using acepromazine in capture operations in order to reduce stress response and prevent its adverse effects in roe deer. The beneficial effect was not only due to the sedative effect of acepromazine, but also to peripheral vasodilatation.
本研究的目的是评估一种短效抗精神病药物（乙酰丙嗪）对狍（Capreolus capreolus）捕获应激反应的影响。1998年、1999年和2001年冬季，通过驱赶网捕获了16只狍。将狍分为两组：治疗组动物接受肌肉注射乙酰丙嗪（0.093 mg/kg±0.003标准误；n = 8），而对照组动物（n = 8）未接受镇静剂。使用心率、体温以及应激的血液学和生化指标来评估抗精神病药物在3小时内的效果。两组捕获后心率均随时间下降（P < 0.05），但治疗组狍心率在捕获后75分钟比对照组（捕获后105分钟）更快趋于稳定。两组体温在45分钟内下降，然后趋于稳定（P < 0.05）。血液参数比较显示，与对照组相比，使用镇静剂的动物红细胞计数（RBC）、淋巴细胞计数、血红蛋白浓度、血细胞比容（PCV）以及血清丙氨酸转氨酶（ALT）、天冬氨酸转氨酶（AST）、肌酸激酶（CK）和乳酸脱氢酶（LDH）活性显著降低（至少P < 0.05）。对照组动物随时间血细胞比容、淋巴细胞计数和血清皮质醇浓度降低（至少P < 0.05），血清肌酐水平升高（P < 0.05），而治疗组随时间红细胞和血红蛋白浓度降低（至少P < 0.05），血清尿素浓度升高（P < 0.05）。最后，两组血清乳酸和钾水平降低，CK、AST、ALT和LDH活性随时间升高。所得结果表明，使用乙酰丙嗪进行捕获操作以减轻应激反应并防止其对狍产生不良影响是合适的。有益效果不仅归因于乙酰丙嗪的镇静作用，还归因于外周血管扩张。
