Sobstyl Michał, Zabek Mirosław, Koziara Henryk
Kliniki Neurochirurgii CMKP, Wojewódzkiego Szpitala Bródnowskiego w Warszawie.
Neurol Neurochir Pol. 2003 Jan-Feb;37(1):203-13.
Among all the extrapiramidal movement disorders Parkinson's disease (PD) is the one most often submitted to neurosurgical treatment. Technical advances in neurosurgery, neuroimaging and neurophysiology, as well as shortcomings of chronic Levodopa medication (i.e. on/off fluctuations, violent dyskinesia and painful dystonia) have greatly contributed to the renewed interest in the surgical treatment of PD. The attainment of a better understanding of the basal ganglia function and of PD pathophysiology has also encouraged centers to treat Parkinson's disease in recent years. This article presents the current model of PD and the rationale for using GPi, thalamus and STN as target sites in stereotactic surgery.
在所有锥体外系运动障碍中，帕金森病（PD）是最常接受神经外科治疗的疾病。神经外科、神经影像学和神经生理学的技术进步，以及左旋多巴长期药物治疗的缺点（即开关波动、剧烈运动障碍和疼痛性肌张力障碍），极大地促进了人们对帕金森病外科治疗的重新关注。近年来，对基底神经节功能和帕金森病病理生理学的更好理解也促使各中心开展帕金森病的治疗。本文介绍了帕金森病的当前模型，以及在立体定向手术中使用苍白球内侧部（GPi）、丘脑和丘脑底核（STN）作为靶点的理论依据。
