Yamane Takashi, Yamauchi Hayato, Abe Naoko, Torio Naomi, Shimada Reika, Senba Takanori, Imaizumi Yasuhiko, Nomura Tetsuhiko
Department of Internal Medicine, Hyogo Prefectual Awaji Hospital, Sumoto-city, Hyogo.
Ryumachi. 2003 Jun;43(3):544-8.
To clarify the usefulness of measuring serum amyloid A (SAA) levels in patients with polymyalgia rheumatica (PMR), we compared this parameter to C-reactive protein (CRP).
The study included 10 patients with PMR, who could be prospectively followed up from the start of prednisolone (PSL) treatment until the CRP level decreased to 1 mg/dl or less. When the CRP level decreased, the subjects were divided into the group in which the symptom persisted (n = 6) and those in which the symptom disappeared (n = 4).
In the group in which the symptom persisted, both CRP and SAA levels were significantly higher. When the CRP level decreased, there was no significant difference in the CRP level between the two groups. However, the mean SAA level in the group in which the symptom persisted (137.8 micrograms/ml) was significantly higher than that in the group in which the symptom disappeared (21.8 micrograms/ml). On the initial consultation, there was a positive correlation between CRP and SAA (R = 0.77). The SAA level was more sensitive than the CRP level (y = 94.899 x -51.22). When the CRP level decreased, SAA was much more sensitive (y = 222.92 x +6.9121), suggesting the usefulness of SAA after the start of PSL treatment.
SAA may be a useful parameter of PMR activity.
为了阐明在风湿性多肌痛（PMR）患者中测量血清淀粉样蛋白A（SAA）水平的有用性，我们将该参数与C反应蛋白（CRP）进行了比较。
该研究纳入了10例PMR患者，这些患者从泼尼松龙（PSL）治疗开始直至CRP水平降至1mg/dl或更低时可进行前瞻性随访。当CRP水平下降时，将受试者分为症状持续组（n = 6）和症状消失组（n = 4）。
在症状持续组中，CRP和SAA水平均显著更高。当CRP水平下降时，两组之间的CRP水平无显著差异。然而，症状持续组的平均SAA水平（137.8微克/毫升）显著高于症状消失组（21.8微克/毫升）。在初次就诊时，CRP和SAA之间存在正相关（R = 0.77）。SAA水平比CRP水平更敏感（y = 94.899x - 51.22）。当CRP水平下降时，SAA更敏感（y = 222.92x + 6.9121），这表明PSL治疗开始后SAA的有用性。
SAA可能是PMR活动的一个有用参数。
