Filoteo J Vincent, Friedrich Frances J, Rilling Laurie M, Davis Jennifer D, Stricker John L, Prenovitz Mark
University of California, Veterans Administration San Diego Healthcare System, San Diego, CA, USA.
J Clin Exp Neuropsychol. 2003 Jun;25(4):441-56. doi: 10.1076/jcen.25.4.441.13874.
Semantic and cross-case identity priming were investigated in nondemented patients with Parkinson's disease (PD) and controls using the Lexical Decision Task. Three conditions were administered that consisted of the presentation of prime and target word pairs. In the semantic priming condition the word pairs were semantically related (e.g., table-CHAIR), in the cross-case identity priming condition the word pairs consisted of the same word (e.g., noise-NOISE), and in the unrelated condition the word pairs were not related semantically (e.g., guns-DEEP). A fourth condition was also administered that consisted of the presentation of a prime word and a pronounceable nonword target (e.g., starved-FORVE). Participants were asked to indicate whether the target was a real word or a nonword. The prime and target were separated by either a short or long (250 ms or 1000 ms) stimulus onset asynchrony (SOA). Results indicated that PD patients displayed normal semantic priming (i.e., faster responding to the target in the semantic condition as compared to the unrelated condition) at both the short and long SOA. Similarly, PD patients displayed normal cross-case identity priming (i.e., faster responding to the target in the identity condition relative to the unrelated condition) at the long SOA. At the short SOA, however, PD patients displayed hyper identity priming relative to controls (134 ms vs. 50 ms). These results suggest that semantic processes are normal in nondemented PD patients but that the processes involved in accessing lexical information may be overly activated in these patients.
使用词汇判定任务，对帕金森病（PD）非痴呆患者和对照组进行了语义和跨案例同一性启动效应的研究。设置了三种条件，包括呈现启动词和目标词对。在语义启动条件下，词对在语义上相关（例如，桌子 - 椅子）；在跨案例同一性启动条件下，词对由相同的词组成（例如，噪音 - 噪音）；在无关条件下，词对在语义上不相关（例如，枪 - 深）。还设置了第四种条件，包括呈现一个启动词和一个可发音的非词目标（例如，饥饿的 - FORVE）。要求参与者指出目标是真词还是非词。启动词和目标词之间的刺激起始间隔（SOA）分为短间隔或长间隔（250毫秒或1000毫秒）。结果表明，PD患者在短SOA和长SOA时均表现出正常的语义启动效应（即，与无关条件相比，在语义条件下对目标的反应更快）。同样，PD患者在长SOA时表现出正常的跨案例同一性启动效应（即，与无关条件相比，在同一性条件下对目标的反应更快）。然而，在短SOA时，PD患者相对于对照组表现出过度的同一性启动效应（134毫秒对50毫秒）。这些结果表明，非痴呆PD患者的语义加工是正常的，但这些患者在获取词汇信息时所涉及的加工过程可能被过度激活。
