Trotti Rosita, Rondanelli Mariangela, Cuzzoni Giovanni, Magnani Barbara, Gabanti Elisa, Ferrari Ettore
Biochemical-Clinical Analysis Laboratory, IRCCS C. Mondino Institute of Neurology, Pavia, Italy.
Funct Neurol. 2003 Apr-Jun;18(2):77-81.
Age-related structural and neurochemical changes occurring in the central nervous system have been related to changes in some rhythmometric parameters. In spite of their clinical importance, only a few studies have investigated the modifications over time of serum electrolytes in senescence. The aim of our study was to evaluate the circadian pattern of serum potassium, chloride, sodium, calcium and phosphorus in 30 clinically healthy elderly subjects, with no cognitive impairment, and to compare the findings with those given by 24 healthy young controls. The subjects were synchronized as regards their daily activities, sleeping/waking habits, time/quality of meals and dietary electrolyte intake. After an overnight fast, samples were taken beginning at 08.00 and every 4 h thereafter until 20.00, and every 2 h from 20.00 to 04.00. Both the young and the elderly subjects exhibited statistically significant circadian rhythms for all serum electrolytes considered. Our findings suggest that circadian organization of serum electrolytes is maintained in physiological aging, even though it should be noted that sodium and phosphorus acrophases differed significantly in the two experimental groups.
中枢神经系统中发生的与年龄相关的结构和神经化学变化与一些节律测量参数的变化有关。尽管其具有临床重要性，但仅有少数研究调查了衰老过程中血清电解质随时间的变化。我们研究的目的是评估30名无认知障碍的临床健康老年受试者血清钾、氯、钠、钙和磷的昼夜模式，并将结果与24名健康年轻对照者的结果进行比较。受试者在日常活动、睡眠/觉醒习惯、用餐时间/质量和饮食电解质摄入量方面保持同步。经过一夜禁食后，从08:00开始取样，此后每4小时取样一次，直至20:00，从20:00至04:00每2小时取样一次。年轻和老年受试者的所有血清电解质均呈现出具有统计学意义的昼夜节律。我们的研究结果表明，在生理衰老过程中，血清电解质的昼夜节律保持不变，尽管应该注意的是，两个实验组中钠和磷的峰值相位存在显著差异。
