Wensveen Celesta, Kagie Marjolein, Veldhuizen Roel, De Groot Christianne, Denny Lynette, Zwinderman Koos, Trimbos Baptist
Department of Obstetrics and Gynecology, the Medical Center Haaglanden, Westeinde Hospital, the Hague, The Netherlands.
Acta Obstet Gynecol Scand. 2003 Sep;82(9):883-9. doi: 10.1034/j.1600-0412.2003.00231.x.
(1) To assess the prevalence of histologically confirmed cervical intraepithelial neoplasia in patients with cervical smears diagnosed as atypical squamous or glandular cells of undetermined significance. (2) To evaluate the role of colposcopy and the presence of human papillomavirus in detecting underlying cervical intraepithelial neoplasia.
In this prospective cohort, 148 women with atypical squamous or glandular cells of undetermined significance were evaluated by colposcopy, histological sampling, and human papillomavirus deoxyribonucleic acid testing.
Histological diagnosis of >/= cervical intraepithelial neoplasia II was found in 10/148 women. Women with a histological >/= cervical intraepithelial neoplasia II had a higher prevalence of >/= two abnormal quadrants (90% vs. 38%</= cervical intraepithelial neoplasia I, p = 0.002) and of high/intermediate-risk human papillomavirus (90% vs. 42% </= cervical intraepithelial neoplasia I, p = 0.005).
Our study shows that premalignant lesions of the cervix were present in 7% of the patients with a cytological diagnosis of atypical squamous or glandular cells of undetermined significance. Colposcopy and human papillomavirus deoxyribonucleic acid testing are both important parameters in detecting >/= cervical intraepithelial neoplasia II.
（1）评估宫颈涂片诊断为意义不明确的非典型鳞状或腺细胞患者中经组织学确诊的宫颈上皮内瘤变的患病率。（2）评估阴道镜检查及人乳头瘤病毒的存在情况在检测潜在宫颈上皮内瘤变中的作用。
在这项前瞻性队列研究中，对148例意义不明确的非典型鳞状或腺细胞女性患者进行了阴道镜检查、组织学取样及人乳头瘤病毒脱氧核糖核酸检测。
148例女性中有10例经组织学诊断为宫颈上皮内瘤变II级及以上。宫颈上皮内瘤变II级及以上的女性中，两个及以上象限异常的患病率更高（90% 对比宫颈上皮内瘤变I级及以下的38%，p = 0.002），高危/中危人乳头瘤病毒的患病率也更高（90% 对比宫颈上皮内瘤变I级及以下的42%，p = 0.005）。
我们的研究表明，细胞学诊断为意义不明确的非典型鳞状或腺细胞的患者中，7%存在宫颈的癌前病变。阴道镜检查及人乳头瘤病毒脱氧核糖核酸检测都是检测宫颈上皮内瘤变II级及以上的重要参数。
