卢森堡宫颈癌筛查中液基细胞学和人乳头瘤病毒检测的介绍。

Introduction of liquid-based cytology and human papillomavirus testing in cervical cancer screening in Luxembourg.

作者信息

Latsuzbaia Ardashel, Hebette Gaëtan, Fischer Marc, Arbyn Marc, Weyers Steven, Vielh Philippe, Schmitt Fernando, Mossong Joël

机构信息

Surveillance and Epidemiology of Infectious Diseases, Laboratoire National de Santé, Dudelange, Luxembourg.

Department of Obstetrics and Gynecology, Ghent University Hospital, Ghent, Belgium.

出版信息

Diagn Cytopathol. 2017 May;45(5):384-390. doi: 10.1002/dc.23678. Epub 2017 Mar 1.

DOI:10.1002/dc.23678

PMID:28247516

Abstract

BACKGROUND

In 2014, liquid-based cytology with HPV triage replaced conventional cytology. The aim of our study was to compare conventional and liquid-based cytology (LBC), estimate the prevalence of abnormal cervical cytology and high risk HPV (hrHPV) infection and their correlation, among screened women in Luxembourg.

METHODS

Between the first January 2013 and 31st December 2015, 315,868 cervical samples from 150,815 women (mean age 42.2 years) were investigated by the national cytology laboratory. Slides were prepared and screened according to European Guidelines. All cytological results were classified according to the Bethesda 2001 system terminology.

RESULTS

The prevalence of abnormal cervical lesions was as follows: atypical squamous cells of undetermined significance (ASC-US), 1.3%; low-grade squamous intraepithelial lesion (LSIL), 1.9%; high-grade squamous intraepithelial lesion (HSIL), 0.4%. The detection rate of cytological lesions was significantly higher with LBC than with conventional cytology. Based on 11,838 samples with concomitant cytology and HPV testing, hrHPV was detected in 9.5, 45.3, 70.0, and 92.6% of women with negative cytology, ASC-US, LSIL, and HSIL, respectively.

CONCLUSION

More cervical lesions were identified using LBC compared to conventional cytology. HrHPV infection was correlated with the severity of intraepithelial lesions. The current findings provide important information to evaluate the prevention of cervical cancer in Luxembourg and for monitoring the future impact of HPV vaccination. Diagn. Cytopathol. 2017;45:384-390. © 2017 Wiley Periodicals, Inc.

摘要

背景

2014年，人乳头瘤病毒（HPV）分流的液基细胞学检查取代了传统细胞学检查。我们研究的目的是比较卢森堡接受筛查女性中传统细胞学检查和液基细胞学检查（LBC），评估宫颈细胞学异常和高危型HPV（hrHPV）感染的患病率及其相关性。

方法

在2013年1月1日至2015年12月31日期间，国家细胞学实验室对150,815名女性（平均年龄42.2岁）的315,868份宫颈样本进行了调查。根据欧洲指南制备并筛查玻片。所有细胞学结果均按照2001年贝塞斯达系统术语进行分类。

结果

宫颈病变异常的患病率如下：意义不明确的非典型鳞状细胞（ASC-US），1.3%；低级别鳞状上皮内病变（LSIL），1.9%；高级别鳞状上皮内病变（HSIL），0.4%。LBC的细胞学病变检出率显著高于传统细胞学检查。基于11,838份同时进行细胞学检查和HPV检测的样本，在细胞学检查阴性、ASC-US、LSIL和HSIL的女性中，hrHPV的检出率分别为9.5%、45.3%、70.0%和92.6%。