Brommeland T, Lindal S, Straume B, Dahl I L, Hennig R
Department of Neurosurgery, University Hospital of Northern Norway, Tromsø, Norway.
Acta Neurol Scand. 2003 Sep;108(3):153-6. doi: 10.1034/j.1600-0404.2003.00115.x.
To evaluate the diagnostic accuracy using frozen sections only and a combination of imprint cytology and frozen sections.
After introduction of imprint cytology as a supplement to frozen sections in 1999, 153 patients with brain tumours underwent stereotactic or open surgery. An equal number of cases prior to 1999 were chosen for comparison. Intraoperative diagnoses were compared with final diagnoses based on paraffin sections of the same tissue samples. The number of delayed intraoperative diagnoses was noted in each patient group.
The combined use of the two techniques improved intraoperative diagnostic accuracy from 87 to 91% while the delayed intraoperative diagnoses were significantly reduced from 30 to 8. The choice of surgical procedure did not affect the outcome of the pathological investigations.
A combination of frozen sections and imprints significantly reduced the number of delayed intraoperative diagnoses. Intraoperative diagnostic accuracy was improved, although not to a statistically significant level. Choice of surgical procedure did not affect the diagnostic outcome.
评估仅使用冰冻切片以及印片细胞学与冰冻切片相结合的诊断准确性。
1999年引入印片细胞学作为冰冻切片的补充方法后，153例脑肿瘤患者接受了立体定向手术或开颅手术。选取1999年之前数量相等的病例作为对照。将术中诊断结果与基于相同组织样本石蜡切片的最终诊断结果进行比较。记录每组患者术中延迟诊断的数量。
两种技术联合使用使术中诊断准确性从87%提高到91%，同时术中延迟诊断显著减少，从30例降至8例。手术方式的选择不影响病理检查结果。
冰冻切片与印片相结合显著减少了术中延迟诊断的数量。术中诊断准确性有所提高，尽管未达到统计学显著水平。手术方式的选择不影响诊断结果。
