Nanarng Vikram, Jacob Sunitha, Mahapatra Debahuti, Mathew Jacob E
Department of Pathology, Dayanand Medical College and Hospital, Ludhiana, Punjab, India.
Department of Pathology, Christian Medical College and Hospital, Ludhiana, Punjab, India.
J Cytol. 2015 Jul-Sep;32(3):153-8. doi: 10.4103/0970-9371.168835.
Intraoperative diagnosis of central nervous system (CNS) lesions is of utmost importance for neurosurgeons to modify the approach at the time of surgery and to decide on further plan of management. The intraoperative diagnosis is challenging for neuropathologists.
The study was undertaken to determine the accuracy of cytological techniques (crush smears and touch imprints), frozen sections of space occupying lesions of the CNS and compare it with histopathological diagnosis.
A total of 75 specimens received intraoperatively were subjected to cytology and frozen section study.
Neoplastic lesions formed the major group with 62 (82.7%) cases while 13 (17.3%) were nonneoplastic. The diagnostic accuracy of "squash smears" was found to be 89.2%. "Touch imprints" showed diagnostic accuracy of 78.4%. The low accuracy of touch imprints was attributed to poor cellular yield. The diagnostic accuracy of "frozen section" was 75.7%. However, the overall diagnostic accuracy was 96%.
We believe that the cytololgical methods and frozen sections are complimentary to each other and both should be used to improve the intraoperative diagnostic accuracy in the CNS lesion.
中枢神经系统（CNS）病变的术中诊断对于神经外科医生在手术时调整手术入路以及决定进一步的治疗方案至关重要。术中诊断对神经病理学家来说具有挑战性。
本研究旨在确定细胞学技术（压片涂片和触摸印片）、中枢神经系统占位性病变冰冻切片的准确性，并将其与组织病理学诊断进行比较。
共对术中收到的75份标本进行了细胞学和冰冻切片研究。
肿瘤性病变占主要部分，有62例（82.7%），而非肿瘤性病变有13例（17.3%）。“压片涂片”的诊断准确率为89.2%。“触摸印片”的诊断准确率为78.4%。触摸印片准确率低归因于细胞产量低。“冰冻切片”的诊断准确率为75.7%。然而，总体诊断准确率为96%。
我们认为细胞学方法和冰冻切片相互补充，两者都应用于提高中枢神经系统病变的术中诊断准确率。
