Leung Ting Fan, Ma Kwok Chiu, Hon Kam Lun, Lam Christopher W K, Wan Helene, Li Chung Yi, Chan Iris H S
Department of Paediatrics, The Chinese University of Hong Kong, Prince of Wales Hospital, Hong Kong SAR, China.
Pediatr Allergy Immunol. 2003 Aug;14(4):296-301. doi: 10.1034/j.1399-3038.2003.00052.x.
Chemokines are responsible for the trafficking of leukocytes to sites of inflammation. Serum chemokine levels were previously shown to be increased in adult patients with atopic dermatitis (AD). We tested whether serum concentrations of chemokines, including macrophage-derived chemokine (MDC), thymus and activation-regulated chemokine (TARC), eotaxin (EOX), interferon gamma inducible protein 10 (IP-10) and monocyte chemotactic protein 1 (MCP-1), are useful inflammatory markers for assessing AD severity in infants and young children. To investigate this, we assessed the severity of AD clinically using the SCORing Atopic Dermatitis (SCORAD) index system. Serum chemokine concentrations were determined by sandwich enzyme immunoassay. Twenty AD patients with a median age of 2.1 years [interquartile range (IQR): 0.6-4.2] were recruited. Their SCORAD score was 23.5 (12.5-33.5). Serum concentrations of MDC, TARC, EOX, IP-10 and MCP-1 were 2551 (1978-3935), 1469 (1125-3070), 68 (57-85), 126 (101-226) and 518 (419-614) pg/ml, respectively. Serum MDC levels correlated with SCORAD (r = 0.608, p = 0.004) and its extent (r = 0.629, p = 0.003) and intensity (r = 0.557, p = 0.011) components. Serum TARC concentration showed weaker correlation with extent (r = 0.474, p = 0.035) and intensity (r = 0.465, p = 0.039) of skin involvement but not SCORAD. The median serum levels of MDC (3131 vs. 2394 pg/ml; p = 0.031) and EOX (80 vs. 61 pg/ml; p = 0.046) were also higher in children with moderate as compared with mild AD. The other chemokines did not correlate with AD severity. In conclusion, our results suggest that serum MDC concentration may be a useful inflammatory marker for assessing AD severity in infants and young children.
趋化因子负责将白细胞运输到炎症部位。先前研究表明，成人特应性皮炎（AD）患者的血清趋化因子水平会升高。我们测试了包括巨噬细胞衍生趋化因子（MDC）、胸腺和活化调节趋化因子（TARC）、嗜酸性粒细胞趋化因子（EOX）、干扰素γ诱导蛋白10（IP-10）和单核细胞趋化蛋白1（MCP-1）在内的血清趋化因子浓度，是否为评估婴幼儿AD严重程度的有用炎症标志物。为了研究这一点，我们使用特应性皮炎评分（SCORAD）指数系统对AD的严重程度进行了临床评估。血清趋化因子浓度通过夹心酶免疫测定法测定。招募了20名AD患者，中位年龄为2.1岁[四分位间距（IQR）：0.6 - 4.2]。他们的SCORAD评分为23.5（12.5 - 33.5）。血清MDC、TARC、EOX、IP-10和MCP-1的浓度分别为2551（1978 - 3935）、1469（1125 - 3070）、68（57 - 85）、126（101 - 226）和518（419 - 614）pg/ml。血清MDC水平与SCORAD（r = 0.608，p = 0.004）及其范围（r = 0.629，p = 0.003）和强度（r = 0.557，p = 0.011）成分相关。血清TARC浓度与皮肤受累范围（r = 0.474，p = 0.035）和强度（r = 0.465，p = 0.039）的相关性较弱，但与SCORAD无关。与轻度AD患儿相比，中度AD患儿的血清MDC（分别为3131 vs. 2394 pg/ml；p = 0.031）和EOX（分别为80 vs. 61 pg/ml；p = 0.046）中位水平也更高。其他趋化因子与AD严重程度无关。总之，我们的结果表明，血清MDC浓度可能是评估婴幼儿AD严重程度的有用炎症标志物。
