Dalal Ilan, Binson Inga, Levine Arie, Somekh Eli, Ballin Ami, Reifen Ram
Pediatric Allergy and Clinical Immunology Unit, Hebrew University, Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel.
Pediatr Allergy Immunol. 2003 Aug;14(4):312-6. doi: 10.1034/j.1399-3038.2003.00040.x.
Recently, we found sesame to be a major cause of severe IgE-mediated food allergic reactions among infants and young children in Israel. The purpose of this study was to describe the different patterns of sesame sensitivity. We have identified three subgroups among our patients (n = 32). Group I (n = 23, M/F; 14/9) consisted of cases with IgE-mediated sesame allergy. The mean age of the first allergic reaction was 11.7 months. Although the main clinical manifestation was urticaria/angiedema (n = 14, 60%), anaphylaxis was the presenting symptom in seven (30%) patients; all of them were younger than 1 year. Sixteen (70%) were found to be allergic to other foods, and other atopic diseases were identified in 18 (78%) patients. Three patients 'outgrew' their allergy within 1-2 years. Group II (n = 2) included cases in whom sesame allergy was ruled out based on a negative skin prick test (SPT) together with a negative open oral challenge. Group III (n = 7) consisted of patients that were found to be SPT positive for sesame as part of a screening for other food allergies. Although sesame products have become fashionable in westernized countries, early exposure may cause sesame to share eventually the same 'noteriety and fate' as peanut - a major cause of severe food allergic reactions.
最近，我们发现芝麻是以色列婴幼儿严重IgE介导的食物过敏反应的主要原因。本研究的目的是描述芝麻敏感性的不同模式。我们在患者中（n = 32）识别出了三个亚组。第一组（n = 23，男/女；14/9）由IgE介导的芝麻过敏病例组成。首次过敏反应的平均年龄为11.7个月。虽然主要临床表现为荨麻疹/血管性水肿（n = 14，60%），但有7名（30%）患者以过敏反应为首发症状；他们均小于1岁。16名（70%）患者还对其他食物过敏，18名（78%）患者患有其他特应性疾病。3名患者在1 - 2年内“摆脱”了过敏。第二组（n = 2）包括基于皮肤点刺试验（SPT）阴性及开放性口服激发试验阴性排除芝麻过敏的病例。第三组（n = 7）由在其他食物过敏筛查中发现芝麻SPT呈阳性的患者组成。尽管芝麻制品在西方国家已变得流行，但早期接触可能最终导致芝麻与花生一样“声名狼藉和命运相同”——花生是严重食物过敏反应的主要原因。
