Akutsu T, Sakai F, Hata T, Iizuka T, Tazaki Y
Department of Internal Medicine, School of Medicine, Kitasato University.
Rinsho Shinkeigaku. 1992 Jul;32(7):701-7.
Clinical and neuroimaging studies were made in twenty-one patients during the attack of eclampsia. Most frequent neurological signs and symptoms were the impairment of consciousness, headache, seizure and visual disturbance. Mean arterial blood pressure increased by 46 mmHg (n = 21) during the attacks. Eight of 9 patients studied by CT and/or MRI showed transient abnormalities on brain images during the attack in the occipital cortex, basal ganglia, and internal and external capsule. The findings were compatible with brain edema and were seen mainly in the white matter. Cerebral blood flow measured by SPECT method in one patient during an attack with visual disturbance showed increased blood flow in the occipital cortex. Acute increase in blood pressure, cerebral hyperperfusion and edema, similar to the pathophysiology of hypertensive encephalopathy, were considered to play an important role in the pathogenesis of eclampsia.
对21例子痫发作期患者进行了临床和神经影像学研究。最常见的神经体征和症状是意识障碍、头痛、癫痫发作和视觉障碍。发作期间平均动脉血压升高46 mmHg（n = 21）。9例接受CT和/或MRI检查的患者中，有8例在发作期脑影像上显示枕叶皮质、基底节以及内囊和外囊出现短暂异常。这些表现符合脑水肿，主要见于白质。1例发作期伴有视觉障碍的患者通过SPECT方法测量的脑血流显示枕叶皮质血流增加。血压急性升高、脑血流灌注过多和水肿，类似于高血压脑病的病理生理过程，被认为在子痫的发病机制中起重要作用。
