Manfredi M, Beltramello A, Bongiovanni L G, Polo A, Pistoia L, Rizzuto N
Dipartimento di Scienze Neurologiche e della Visione, Universitá di Verona, Italy.
Acta Neurol Scand. 1997 Nov;96(5):277-82. doi: 10.1111/j.1600-0404.1997.tb00284.x.
Eclampsia is a rare condition peculiar to pregnant and puerperal women, characterized by clinical pre-eclampsia (hypertension, proteinuria, edema) and generalized seizures. Three cases of eclamptic encephalopathy are reported: CT and MRI demonstrated transient abnormalities in the cortical and subcortical regions of the posterior areas of the brain - namely, parieto-occipital lobes - associated with occasional involvement of basal ganglia and/or brainstem. Pathogenesis is still unclear. Strict similarity with the pathological findings characterizing hypertensive encephalopathy suggests that a focal impairment in cerebral autoregulation may be the cause of vasodilation and fluid extravasation leading to hydrostatic edema; selective involvement of posterior areas could be explained by their lesser degree of adrenergic innervation supporting circulatory autoregulation mechanisms.
子痫是妊娠和产褥期妇女特有的一种罕见病症，其特征为临床先兆子痫（高血压、蛋白尿、水肿）和全身性惊厥。本文报告了3例子痫性脑病病例：CT和MRI显示大脑后部区域（即顶枕叶）的皮质和皮质下区域出现短暂异常，基底节和/或脑干偶尔受累。发病机制仍不清楚。与高血压脑病的病理表现极为相似，提示脑自动调节功能的局灶性损害可能是导致血管扩张和液体外渗从而引起静水压性水肿的原因；后部区域的选择性受累可以用其支持循环自动调节机制的肾上腺素能神经支配程度较低来解释。
