Hughes B, Durran A, Langford N J, Mutimer D
Birmingham Medical School, Edgbaston, Birmingham, UK.
J Clin Pharm Ther. 2003 Aug;28(4):307-10. doi: 10.1046/j.1365-2710.2003.00497.x.
Pack sizes of paracetamol available to the public were reduced by legislation in 1998.
To study the effect of the legislation on paracetamol poisoning related admissions to an accident and emergency department and to a tertiary referral liver unit.
Data were obtained from the University Hospitals, Birmingham, UK (UHB) Trust Information Service and the Queen Elizabeth Hospital liver unit records on (a) the number of patients admitted to hospital because of paracetamol overdose and (b) the number of patients admitted to the liver unit with parcetamol-induced hepatotoxicity.
Prior to legislation, an average of 360 people a year were admitted to UHB. However, following the change in legislation the number of admissions has fallen to an average of 250 people per year. This represents a reduction of 31%. Prior to legislation, an average of 76 people per year were admitted to the liver unit. Post-legislation this number has dropped to an average of 38 per year representing a reduction of 50%.
Legislation restricting paracetamol pack-size reduced the incidence and severity of poisoning.
1998年通过立法减少了向公众提供的扑热息痛包装规格。
研究该立法对因扑热息痛中毒而入住急诊科和三级转诊肝病科的影响。
数据取自英国伯明翰大学医院（UHB）信托信息服务中心以及伊丽莎白女王医院肝病科记录，内容包括（a）因扑热息痛过量而住院的患者数量，以及（b）因扑热息痛诱发肝毒性而入住肝病科的患者数量。
立法前，UHB每年平均有360人入院。然而，立法变更后，入院人数降至每年平均250人。这意味着减少了31%。立法前，肝病科每年平均有76人入院。立法后，这一数字降至每年平均38人，减少了50%。
限制扑热息痛包装规格的立法降低了中毒的发生率和严重程度。
