Donohoe E, Walsh N, Tracey J A
National Poisons Information Centre, Beaumont Hospital, Dublin 9.
Ir J Med Sci. 2006 Jul-Sep;175(3):40-2. doi: 10.1007/BF03169171.
Legislation was introduced in Ireland in October 2001 to control the sale of paracetamol in non-pharmacy outlets. Preparations are now limited to 12 tablets per pack and only one pack can be sold per transaction.
To assess the impact of this legislation on acute deliberate paracetamol overdoses.
We reviewed acute deliberate paracetamol overdoses reported during two 24-months periods before and after October 2001. We grouped cases according to the number of tablets taken and compared the periods using chi-square and Mann-Whitney tests.
The number of tablets taken in acute deliberate paracetamol overdose fell significantly after October 2001 (chi2 = 11.663, P = 0.0029). Fewer cases involved 12-24 tablets (U = 74, P < 0.001) and fewer cases involved more than 24 tablets (U = 131.5, P = 0.0006).
Legislation controlling sale and packaging of paracetamol preparations appears to be associated with a significant fall in the number of tablets taken in acute deliberate paracetamol overdoses.
2001年10月爱尔兰出台立法，以控制对乙酰氨基酚在非药店渠道的销售。目前制剂限每包12片，且每次交易仅能售卖一包。
评估该立法对急性故意过量服用对乙酰氨基酚事件的影响。
我们回顾了2001年10月前后两个24个月期间报告的急性故意过量服用对乙酰氨基酚事件。我们根据服用的片数对病例进行分组，并使用卡方检验和曼-惠特尼检验对这两个时期进行比较。
2001年10月后，急性故意过量服用对乙酰氨基酚所服用的片数显著下降（卡方 = 11.663，P = 0.0029）。涉及12 - 24片的病例减少（U = 74，P < 0.001），涉及超过24片的病例也减少（U = 131.5，P = 0.0006）。
控制对乙酰氨基酚制剂销售和包装的立法似乎与急性故意过量服用对乙酰氨基酚时所服用的片数显著减少有关。
