Feng Z Y
Tianjin An Ding Psychiatric Hospital.
Zhonghua Shen Jing Jing Shen Ke Za Zhi. 1992 Oct;25(5):306-9, 318-9.
The frequency of sex chromatin of 2000 cases of mental patients are observed in this paper. The frequency of Y chromatin in male and X chromatin in female was 28.01% and 26.86% respectively, whereas only 16.97% and 17.84% respectively in the control group. The mental patient group is higher than the control group significantly (P < 0.0001). It may be influenced by some psychotropic drugs and the factor of course. Positive X chromatin in the male patients was 8 cases and karyotypes of chromosome was XXY type all. The incidence of XXY type is 0.77% and significant higher than the control group (0.18%, P < 0.01). It suggested that ratio of add one X chromosome in the male mental patients be obviously increased. The authors indicated if this examination be routinely used in clinic that would prevent misdiagnosis and would raise accuracy of diagnosis.
本文观察了2000例精神病患者的性染色质频率。男性的Y染色质频率和女性的X染色质频率分别为28.01%和26.86%，而对照组分别仅为16.97%和17.84%。精神病患者组显著高于对照组（P<0.0001）。这可能受一些精神药物及病程因素的影响。男性患者中阳性X染色质有8例，染色体核型均为XXY型。XXY型的发生率为0.77%，显著高于对照组（0.18%，P<0.01）。提示男性精神病患者中额外增加一条X染色体的比例明显增加。作者指出，若将此项检查常规应用于临床，可防止误诊并提高诊断准确性。
