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Lymphocytic infiltration and expression of inducible nitric oxide synthase in human duodenal and colonic mucosa is a characteristic feature of ankylosing spondylitis.淋巴细胞浸润以及诱导型一氧化氮合酶在人十二指肠和结肠黏膜中的表达是强直性脊柱炎的一个特征性表现。
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2
GASTRIC MUCOSAL INJURY BY FATTY AND ACETYLSALICYLIC ACIDS.脂肪酸和乙酰水杨酸所致的胃黏膜损伤
Gastroenterology. 1964 Mar;46:245-53.
3
Ability of some antirheumatic drugs to uncouple oxidative phosphorylation.某些抗风湿药物解偶联氧化磷酸化的能力。
Nature. 1962 Dec 29;196:1323-4. doi: 10.1038/1961323a0.
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Serious lower gastrointestinal clinical events with nonselective NSAID or coxib use.使用非选择性非甾体抗炎药或昔布类药物出现的严重下消化道临床事件。
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新教条还是旧教条？

New dogmas or old?

作者信息

Whittle B J R

机构信息

William Harvey Research Institute, Barts and The London, Queen Mary's School of Medicine, Charterhouse Square, London EC1M 6BQ, UK.

出版信息

Gut. 2003 Sep;52(9):1379-81. doi: 10.1136/gut.52.9.1379.

DOI:10.1136/gut.52.9.1379
PMID:12912874
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1773776/
Abstract

Recent experimental studies may undermine our understanding of the gastrointestinal side effects of non-steroidal anti-inflammatory drugs and cast a shadow on the original concept that underpins the development of the recent addition to the clinical anti-inflammatory armamentarium, the COX-2 selective inhibitors. But is this just a passing cloud or a total eclipse of the COX theory?

摘要

近期的实验研究可能会削弱我们对非甾体抗炎药胃肠道副作用的理解，并给支撑临床抗炎药物新成员——COX-2选择性抑制剂研发的原有概念蒙上阴影。但这只是暂时的阴霾，还是COX理论的彻底覆灭呢？