Jiao Z Y
Department of Urology, Tong Ren Hospital, Beijing.
Zhonghua Zhong Liu Za Zhi. 1992 Sep;14(5):379-81.
Sixty-eight patients with carcinoma of the urinary bladder were treated with photodynamic therapy (PDT). The results demonstrated that the tumors of 1-2 cm in diameter had best results, the tumors of 2-4 cm in diameter should be irradiated repeatedly or with intensified energy density, whereas those above 4 cm in diameter or those that had infiltrated deep muscular layer or neck of the bladder showed poor results. In this group, the total effective rate is 91%, the 5 year cure rate is 71.1%, and the 5 year recurrence rate is only 27.9%. In addition, we used preventive photodynamic irradiation of total bladder in 14 cases with bladder carcinoma who had undergone treatment. The 2 year recurrence rate was 7.1% (1 case), demonstrating a very promising result. The mechanism of tumor destruction with PDT action, the reasons for low recurrence rate, the advantages and disadvantages of this therapy were also discussed.
68例膀胱癌患者接受了光动力疗法（PDT）治疗。结果表明，直径1 - 2厘米的肿瘤治疗效果最佳，直径2 - 4厘米的肿瘤应重复照射或提高能量密度，而直径超过4厘米或已浸润至膀胱肌层深部或膀胱颈部的肿瘤治疗效果较差。该组患者的总有效率为91%，5年治愈率为71.1%，5年复发率仅为27.9%。此外，我们对14例已接受治疗的膀胱癌患者进行了全膀胱预防性光动力照射。2年复发率为7.1%（1例），显示出非常有前景的结果。还讨论了光动力疗法破坏肿瘤的机制、低复发率的原因以及该疗法的优缺点。
