Tian M E
Henan Tumor Hospital, Zhengzhou.
Zhonghua Zhong Liu Za Zhi. 1989 Jul;11(4):304-6.
Thirty patients with bladder carcinoma treated by photodynamic therapy (PDT) with hematoporphyrin derivative are presented. 24, 48 and/or 72 hours after intravenous injection of DHE 1.5-2.0 mg/kg or Y-HpD 5.0 mg/kg, the tumor was irradiated with 630 nm wavelength of argon dye laser via a quartz optic fibre inserted through the forceps channel of the cystoscope. Of the 30 patients treated, CR was obtained in 14 cases, PR in 13 cases and NR in 3 cases 1-3 months after therapy with a total effective rate of 90%. Among the 78 tumors found in the 30 cases, 52 were completely eradicated with a eradication rate of 66.7%. Photodynamic therapy is therefore useful in the treatment of transitional-cell carcinoma of the bladder. Yet, controlled trials are required to assess its place in the combined treatment of carcinoma of the bladder. Post PDT morphologic changes in the tumor, side effects, indication, advantages and disadvantages of this therapy are discussed.
本文报告了30例采用血卟啉衍生物光动力疗法（PDT）治疗的膀胱癌患者。静脉注射1.5 - 2.0mg/kg的二血卟啉醚（DHE）或5.0mg/kg的Y-血卟啉衍生物（Y-HpD）后24、48和/或72小时，通过插入膀胱镜钳道的石英光纤，用波长630nm的氩离子染料激光照射肿瘤。30例接受治疗的患者中，治疗后1 - 3个月，14例获得完全缓解（CR），13例部分缓解（PR），3例未缓解（NR），总有效率为90%。30例患者共发现78个肿瘤，其中52个完全消除，消除率为66.7%。因此，光动力疗法对膀胱移行细胞癌的治疗是有效的。然而，需要进行对照试验来评估其在膀胱癌综合治疗中的地位。本文还讨论了光动力疗法后肿瘤的形态学变化、副作用、适应证以及该疗法的优缺点。
