Lee Keun Tae, Min Hong Ki, Chung Pyung Rim, Chang Jae Kyung
Department of Parasitology, Yonsei University College of Medicine, Seoul, Korea.
Kisaengchunghak Chapchi. 1976 Jun;14(1):51-60. doi: 10.3347/kjp.1976.14.1.51.
To observe the possibility of human visceral larva migrans due to eating of raw liver of domestic animals, especially of cattle, and also to serve as a good reference for adequate sanitary measures, the investigation survey was carried out from May 1975 to May 1976. From the subjects of a l,048 inhabitants (male 558, female 490) in five localities including two Provinces and three different cities, food habit was studied by questionnaire mannual. Larvae isolated from liver tissues of cattle, and pig were identified. Experimental observation on the chicken and mice infected with Toxocara canis was undertaken to draw a assumption of possibility inducing human visceral larva migrans. The results obtained from the present study are summarized. 1. A part of Korean people has the habit to eat the livers of cattle, fowl, pig and dog raw. Eating rate of raw beef liver was 37.8% out of l,048 inhabitants, and its rate was higher markedly in male(57.7%) than in female (15. 1%), and the highest rate among the group of 31-40 years old. Eating rate of raw liver of fowl was 5.9%, pig 5.3%, and dog 2.5%. 2. Larva recovery rate from beef liver was 11.8% out of 195 samples and 72.0% of total detected 1arvae were identified as Toxocara(=Neoascaris) vitulorum. From pig liver, larvae of nematoda were found in 6.4% out of 109 samples but no larva was detected from 120 fowl livers. 3. Larvae detected from one-half of tissues and organs of infected chicken with about 2,000 Toxocara canis eggs were 8-245 in number, and 85-100% of recovered larvae were from their 1iver tissues. 4. Toxocara canis larvae, 45, 31, 42 and 23 in number at 3rd, 14th, 25th and 55th day in one-half of the tissues and organs after infection respectively, were demonstrated from the mice infected with 500 larvae collected from infected chicken liver. Most of the larvae were recovered from the carcass of the mouse. It was approved the larvae isolated from chicken possess infectivity to the mice. 5. Typical eosinophilic granulomatous change was not observed in the liver tissue of the infected chicken at 20th day after infection. As it summarized above, the liver of various domestic animals is the favorite tissue for migration of nematodes larvae. Therefore, the possibility of human visceral larva migrans may be induced due to eating of raw liver of domestic animals.
为观察因食用家畜尤其是牛的生肝脏而导致人体内脏幼虫移行症的可能性，并为采取适当的卫生措施提供良好参考，于1975年5月至1976年5月进行了此项调查研究。在包括两个省份和三个不同城市的五个地区，对1048名居民（男性558名，女性490名）进行了调查，通过问卷调查手册研究其饮食习惯。对从牛和猪的肝脏组织中分离出的幼虫进行了鉴定。对感染犬弓首线虫的鸡和小鼠进行了实验观察，以推测诱发人体内脏幼虫移行症的可能性。现将本研究所得结果总结如下。1. 部分韩国人有生食牛、禽、猪和狗肝脏的习惯。在1048名居民中，生食牛肝的比例为37.8%，男性（57.7%）的比例明显高于女性（15.1%），且在31 - 40岁年龄组中比例最高。生食禽肝的比例为5.9%，猪为5.3%，狗为2.5%。2. 在195份牛肝样本中，幼虫检出率为11.8%，所检出幼虫中72.0%被鉴定为犊弓首线虫（=新蛔虫）。在109份猪肝样本中，6.4%发现有线虫幼虫，但在120份禽肝样本中未检出幼虫。3. 用约2000个犬弓首线虫卵感染鸡，在感染鸡的一半组织和器官中检出的幼虫数量为8 - 245条，回收幼虫的85 - 100%来自肝脏组织。4. 分别在感染后第3天、第14天、第25天和第55天，从感染了从感染鸡肝中收集的500条幼虫的小鼠的一半组织和器官中，分别检出45条、31条、42条和23条犬弓首线虫幼虫。大多数幼虫是从小鼠尸体中回收的。证实从鸡分离出的幼虫对小鼠具有感染性。5. 在感染后第20天，感染鸡的肝脏组织中未观察到典型的嗜酸性肉芽肿性变化。综上所述，各种家畜的肝脏是线虫幼虫移行的喜爱组织。因此，食用家畜生肝脏可能诱发人体内脏幼虫移行症。
