Rim Han Jong, Ha Joung Hwan, Lee Joon Sang, Hyun Il, Uh Kwang Bon
Department of Parasitology and Institute for Tropical Endemic Diseases, College of Medicine, Korea University, Seoul, Korea.
Kisaengchunghak Chapchi. 1974 Dec;12(2):141-146. doi: 10.3347/kjp.1974.12.2.141.
A single dose (2.0, 5.0, 10.0 mg/kg) of pyrantel embonate given to three groups consisting 301 children with Ascaris lumbricoides infection achieved a cure rate of 91.3%, 94.4% and 98.9% respectively. Whereas in the other two groups of 71 and 75 patients who received 75 mg/kg body weight with piperazine adipate 2 or 3 consecutive days, the cure rates were 62.0% and 74.7% respectively. Administration of a single recommended dose of santonin-kainic acid complex given to 77 patients achived a cure rate of 80.5% with 91.0% of egg reduction rate. The cure rate resulting from a single lowest dose 2.5 mg/kg pyrantel embonate was significantly higher than those of piperazine adipate and santonin-kainic acid complex in the mass treatment for ascariasis. in addition to the group of 2.5 mg/kg pyrantel embonate treatment, the side effect was lesser than those of the other groups. Considering the efficacy and safety of pyrantel embonate against Ascaris lumbricoides, it would be one of the useful agents for the mass treatment of Ascaris control.
给三组共301名感染蛔虫的儿童分别单次服用2.0、5.0、10.0毫克/千克的双羟萘酸噻嘧啶，治愈率分别为91.3%、94.4%和98.9%。而另外两组分别有71名和75名患者，连续2天或3天接受75毫克/千克体重的己二酸哌嗪治疗，治愈率分别为62.0%和74.7%。给77名患者单次服用推荐剂量的山道年- kainic酸复合物，治愈率为80.5%，虫卵减少率为91.0%。在蛔虫病群体治疗中，单次最低剂量2.5毫克/千克双羟萘酸噻嘧啶的治愈率显著高于己二酸哌嗪和山道年- kainic酸复合物。除2.5毫克/千克双羟萘酸噻嘧啶治疗组外，其他组的副作用较小。考虑到双羟萘酸噻嘧啶对蛔虫的疗效和安全性，它将是蛔虫病群体防治的有效药物之一。
