Seo Byong Seol, Hahn Hyung Joo, Lee Joon Sang, Koo Bon Yong
Department of Parasitology and Institute of Endemic Diseases, College of Medicine, Seoul National University, Korea.
Kisaengchunghak Chapchi. 1969 Dec;7(3):201-204. doi: 10.3347/kjp.1969.7.3.201.
The anthelminthic effect of phenylene-diisothiocyanate-(1,4)(=Jonit) was studied on the eighty three cases infected with Ancylostoma duodenale. For the evalution, the number of eggs per gram of feces on all these cases was calculated before treatment. The follow-up for the egg reduction was carried out over a period of four weeks. The sixty-seven cases were treated in dosage schedule of 3 x 100 mg every 12 hours. The cure rates-the rate of negative conversion of eggs-was 74.6 percent and the total egg reduction rate of 94.2% was obtained. The ten out of 14 cases treated in the dosage schedule of 2 x 100 mg every 12 hours showed 100% egg reduction and the cure rate was 71.4%. In this group. the total egg reduction rate of 78.6% was noted. In the dosage schedule of 2 x 50 mg every 12 hours the remainder, two out of total 83 cases showed 100% egg reduction. Side effects were observed as being mild, 51 cases (56.6%) were free of side reactions and the most frequently noted side effects were vertigo and diarrhea. From the above results, it is concluded that Jonit is an effective antheminthic against Ancylostoma duodenale and its effectiveness is quite equivalent to that of a known recommended anti-hookworm products.
研究了亚苯基二异硫氰酸酯 - (1,4)(=乔尼特)对83例十二指肠钩虫感染者的驱虫效果。为了进行评估，在治疗前计算了所有这些病例每克粪便中的虫卵数。在四周的时间内对虫卵减少情况进行了随访。67例患者按照每12小时3×100毫克的剂量方案进行治疗。治愈率——虫卵转阴率——为74.6%，总虫卵减少率为94.2%。在每12小时2×100毫克剂量方案治疗的14例患者中，有10例虫卵减少率达100%，治愈率为71.4%。在该组中，总虫卵减少率为78.6%。在每12小时2×50毫克剂量方案中，83例患者中的其余2例虫卵减少率达100%。观察到副作用较轻，51例(56.6%)无副作用反应，最常出现的副作用是眩晕和腹泻。从上述结果可以得出结论，乔尼特是一种有效的抗十二指肠钩虫驱虫药，其效果与已知推荐的抗钩虫产品相当。
