不同剂量甲苯咪唑治疗钩虫感染的对比研究

Comparative study of different doses of mebendazole in hookworm infection.

作者信息

Nontasut P, Singhasivanon V, Maipanich W, Yamput S, Visiassuk K

机构信息

Department of Helminthology, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand.

出版信息

Southeast Asian J Trop Med Public Health. 1987 Jun;18(2):211-4.

PMID:3672183

Abstract

Sixty six children (40 males, 26 females) aged from 4 to 14 years with hookworm infection were treated with mebendazole. Thirty one and 35 children were treated with mebendazole 300 mg single dose and 600 mg conventional regimen respectively. Stool examination by Kato-Katz technique were done for 3 consecutive days before treatment and on day 14-16, 21-23 after treatment. The cure rate with 300 mg mebendazole was 16.1% with 90.9% egg reduction while 600 mg mebendazole gave 91.4% cure rate with 99.5% egg reduction. No side effects were observed in all children. Four hundred and six adult worms were identified, 99% were Necator Americanus, 0.5% Ancylostoma duodenale and 0.5% Ancylostoma ceylanicum.

摘要

66名4至14岁感染钩虫的儿童（40名男性，26名女性）接受了甲苯达唑治疗。31名和35名儿童分别接受了300毫克单剂量甲苯达唑和600毫克传统方案治疗。在治疗前连续3天以及治疗后第14 - 16天、21 - 23天采用改良加藤厚涂片法进行粪便检查。300毫克甲苯达唑的治愈率为16.1%，虫卵减少率为90.9%，而600毫克甲苯达唑的治愈率为91.4%，虫卵减少率为99.5%。所有儿童均未观察到副作用。共鉴定出406条成虫，其中99%为美洲板口线虫，0.5%为十二指肠钩口线虫，0.5%为锡兰钩口线虫。