Fultz Nancy H, Ofstedal Mary Beth, Herzog A Regula, Wallace Robert B
Institute for Social Research, University of Michigan, Ann Arbor, MI, USA.
J Aging Health. 2003 Aug;15(3):465-81. doi: 10.1177/0898264303253502.
To understand the role of cognitive impairment and depressive symptoms on functional outcomes of stroke and diabetes. Evaluation approaches to functional outcomes have rarely focused on the presence of specific comorbidities, particularly those involving mental health disorders.
Data are from the AHEAD cohort of the Health and Retirement Study (HRS), a nationally representative panel of persons 70+ years of age in 1993. Analyses are limited to 5,646 self-respondents for whom functional outcome data are available in 1995. Additive and interactive multiple regression models are compared for each outcome and focal condition combination.
The additive model is sufficient for the majority of outcome and focal condition combinations. The interaction term is significant in 4 of 12 comparisons.
Stroke, diabetes, cognitive impairment, and depressive symptoms exhibit strong independent effects on physical functioning. Support for the hypothesis that cognitive impairment and depression exacerbate the impact of stroke and diabetes is more limited.
了解认知障碍和抑郁症状对中风和糖尿病功能结局的作用。功能结局的评估方法很少关注特定合并症的存在，尤其是那些涉及精神健康障碍的合并症。
数据来自健康与退休研究（HRS）的AHEAD队列，该队列是1993年全国代表性的70岁及以上人群样本。分析仅限于1995年有功能结局数据的5646名自行应答者。对每个结局和焦点状况组合比较相加和交互多重回归模型。
相加模型对大多数结局和焦点状况组合而言已足够。交互项在12项比较中的4项中具有显著性。
中风、糖尿病、认知障碍和抑郁症状对身体功能表现出强烈的独立影响。认知障碍和抑郁会加剧中风和糖尿病影响这一假设的证据较为有限。
