Tsocheva N, Toshkova R, Filchev A
Institute of Parasitology, Bulgarian Academy of Sciences, Sofia.
Folia Parasitol (Praha). 1992;39(4):387-90.
Biologically active substances (BAS) were isolated from the tissues of Fasciola hepatica L. and from F. hepatica-infected rat liver by ethanol precipitation from aqueous tissue homogenates. A marked inhibiting effect of the newly isolated BAS on hepatoma MC29 cell culture proliferation and a slight inhibiting effect of the newly isolated BAS on myeloma cell culture proliferation was found. The strongest inhibiting effect was by BAS isolated from the tissues of F. hepatica. The inhibiting effect of the BAS isolated from F. hepatica-infected liver was stronger than the effect of the BAS isolated from normal liver tissue.
通过从组织水匀浆中乙醇沉淀，从肝片吸虫组织和感染肝片吸虫的大鼠肝脏中分离出生物活性物质（BAS）。发现新分离的BAS对肝癌MC29细胞培养增殖有显著抑制作用，对骨髓瘤细胞培养增殖有轻微抑制作用。从肝片吸虫组织中分离出的BAS抑制作用最强。从感染肝片吸虫的肝脏中分离出的BAS的抑制作用强于从正常肝组织中分离出的BAS的作用。
