提取物可诱导哺乳动物细胞死亡。
Extract Induces Cell Death of Mammalian Cells.
作者信息
Ferreira Stephanie, Fernandes Ruben, Botelho Monica C
机构信息
Escola Superior de Saúde, Instituto Politécnico do Porto, Portugal.
I3S, Instituto de Investigação e Inovação da Universidade do Porto, Portugal.
出版信息
Antiinfect Agents. 2018;16(2):144-146. doi: 10.2174/1570180815666180531102555.
BACKGROUND
Fascioliasis is a neglected tropical disease that affects poor people from poor and developing countries. In the world, it has been estimated that at least 2.6 million people are affected with this disease. The International agency for Research on Cancer, states that and , also liver flukes, are considered as definitive causes of cholangiocarcinoma. However, fascioliasis caused by has not been associated with cancer to date. There are not any known causative associations between this parasite and liver cancer (cholangiocarcinoma).
METHODS
Chine Hamster Ovary (CHO) cells were treated with extracts and cell proliferation was assessed by using the indirect method for estimating cell number based on the mitochondrial activity with MTS cell proliferation reagent. We observed unexpected death of these cells when treated with extracts.
RESULTS
We now hypothesize that this parasite could be used as a medically-important trematode pathogen in cancer therapy.
背景
肝片吸虫病是一种被忽视的热带疾病，影响着贫穷和发展中国家的贫困人口。据估计，全球至少有260万人感染这种疾病。国际癌症研究机构指出，[此处原文缺失部分内容]以及肝吸虫，被认为是胆管癌的确切病因。然而，迄今为止，由[此处原文缺失寄生虫名称]引起的肝片吸虫病尚未与癌症相关联。这种寄生虫与肝癌（胆管癌）之间不存在任何已知的因果关联。
方法
用[此处原文缺失寄生虫名称]提取物处理中国仓鼠卵巢（CHO）细胞，并使用基于线粒体活性的MTS细胞增殖试剂通过间接方法评估细胞数量来评估细胞增殖。当用[此处原文缺失寄生虫名称]提取物处理时，我们观察到这些细胞意外死亡。
结果
我们现在假设这种寄生虫可作为癌症治疗中具有重要医学意义的吸虫病原体。
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