Trouw L A, Seelen M A, Daha M R
Department of Nephrology, D3-P-39, Leiden University Medical Center, Albinusdreef 2, 2333 ZA Leiden, The Netherlands.
Mol Immunol. 2003 Sep;40(2-4):125-34. doi: 10.1016/s0161-5890(03)00105-6.
The complement system is involved in several aspects of renal disease, including primary renal diseases, dialysis and renal transplant rejection. Initially, a role for complement in renal disease was inferred solely from the deposition of complement components in affected kidneys and changes in complement levels in the circulation during active disease. Recent studies have shown how complement modulates the onset, development and the resolution of renal disease. Current research provides clues on the role of individual complement components and activation pathways as well as possible modes of complement regulation in the management of renal disease.
补体系统参与肾脏疾病的多个方面，包括原发性肾脏疾病、透析及肾移植排斥反应。最初，补体在肾脏疾病中的作用仅从补体成分在受累肾脏中的沉积以及疾病活动期循环中补体水平的变化推断而来。最近的研究表明了补体如何调节肾脏疾病的发生、发展及转归。目前的研究为各个补体成分和激活途径的作用以及补体调节在肾脏疾病管理中的可能模式提供了线索。
