Matkó János
Department of Immunology, Eötvös Lorand University, Pázmány P. sétány 1/C, 1117 Budapest, Hungary.
Trends Pharmacol Sci. 2003 Aug;24(8):385-9. doi: 10.1016/S0165-6147(03)00198-6.
Diverse K(+) channels exhibit differential expression and function in human lymphocytes. Voltage-gated and Ca(2+)-activated K(+) channels have a significant impact on both T-cell activation and the overall immune response. A recent study on the plasma membrane organization of Kv1.3 K(+) channels in human T cells provides new insights into the immunoregulatory functions of K(+) channels, which might result in new and improved immune suppression protocols targeted to ion channels and/or T-cell signaling and accessory molecules.
多种钾离子通道在人类淋巴细胞中表现出不同的表达和功能。电压门控钾离子通道和钙激活钾离子通道对T细胞活化和整体免疫反应均有显著影响。最近一项关于人类T细胞中Kv1.3钾离子通道质膜组织的研究为钾离子通道的免疫调节功能提供了新见解，这可能会带来针对离子通道和/或T细胞信号传导及辅助分子的全新且改进的免疫抑制方案。
