类风湿关节炎中的遗传学
Genetics in rheumatoid arthritis.
作者信息
Huizinga Tom W J
机构信息
Department of Rheumatology, C4-R, Leiden University Medical Center, P.O. Box 9600, RC 2300, Leiden, The Netherlands.
出版信息
Best Pract Res Clin Rheumatol. 2003 Oct;17(5):703-16. doi: 10.1016/s1521-6942(03)00040-8.
This chapter reviews the latest original research on the genetics of rheumatoid arthritis (RA), with a focus on its relevance for the clinical rheumatologist. The following questions will be dealt with in order to appreciate the recent progress in this field. * Why is a knowledge of genetics useful for an understanding of the pathogenesis of RA? * Is a knowledge of genetic risk factors relevant for day-to-day clinical practice? * What methods are used for identifying genetic risk factors? * Which genetic regions have been identified in susceptibility to RA? * What risk factors have been identified? * What are the future prospects and research agenda?
本章回顾了类风湿关节炎（RA）遗传学方面的最新原创研究，重点关注其对临床风湿病学家的相关性。为了了解该领域的最新进展，将探讨以下问题。* 为什么遗传学知识有助于理解RA的发病机制？* 遗传风险因素的知识与日常临床实践相关吗？* 用于识别遗传风险因素的方法有哪些？* 在RA易感性方面已确定了哪些基因区域？* 已确定了哪些风险因素？* 未来的前景和研究议程是什么？
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