Nakazato Michiko, Hashimoto Kenji, Shimizu Eiji, Kumakiri Chikara, Koizumi Hiroki, Okamura Naoe, Mitsumori Makoto, Komatsu Naoya, Iyo Masaomi
Department of Psychiatry, Chiba University Graduate School of Medicine, Chiba, Japan.
Biol Psychiatry. 2003 Aug 15;54(4):485-90. doi: 10.1016/s0006-3223(02)01746-8.
Several lines of evidence suggest that brain-derived neurotrophic factor (BDNF) plays a role in the regulation of eating behavior. Because of its role in eating behavior, which is especially relevant to eating disorders, BDNF is an attractive candidate for investigation of potential biological markers of eating disorders such as bulimia nervosa (BN) and anorexia nervosa (AN).
We enrolled 18 female patients with BN, 12 female patients with AN, and 21 age-matched female normal control subjects in this study. Eating-related psychopathology and depressive symptoms were evaluated using the Bulimic Investigatory Test, Edinburgh (BITE) and the Hamilton Depression Rating Scale (HDRS). Serum BDNF levels were measured by a sandwich enzyme-linked immunosorbent assay.
Serum levels of BDNF in the patients with AN or BN were significantly (p<.0001) decreased compared with those of normal control subjects, and serum BDNF levels in the patients with AN were significantly (p=.027) lower than those in patients with BN. A significant positive correlation (r=.378, p=.006) between serum BDNF levels and body mass index in all of the subjects was detected. Furthermore, there was a significant positive correlation (r=.435, p=.015) between the BITE symptom scale score and HDRS in these patients.
The present study suggests that BDNF may play a role in the pathophysiology of eating disorders.
多项证据表明，脑源性神经营养因子（BDNF）在饮食行为调节中发挥作用。由于其在饮食行为中的作用，这与饮食失调尤其相关，BDNF是研究诸如神经性贪食症（BN）和神经性厌食症（AN）等饮食失调潜在生物标志物的一个有吸引力的候选对象。
本研究纳入了18名患有BN的女性患者、12名患有AN的女性患者以及21名年龄匹配的女性正常对照受试者。使用爱丁堡贪食症调查测试（BITE）和汉密尔顿抑郁量表（HDRS）评估与饮食相关的精神病理学和抑郁症状。通过夹心酶联免疫吸附测定法测量血清BDNF水平。
与正常对照受试者相比，AN或BN患者的血清BDNF水平显著降低（p<0.0001），且AN患者的血清BDNF水平显著低于BN患者（p = 0.027）。在所有受试者中检测到血清BDNF水平与体重指数之间存在显著正相关（r = 0.378，p = 0.006）。此外，这些患者的BITE症状量表评分与HDRS之间存在显著正相关（r = 0.435，p = 0.015）。
本研究表明BDNF可能在饮食失调的病理生理学中发挥作用。
