血清脑源性神经营养因子水平在 2 型糖尿病患者及其与认知障碍的关系：一项荟萃分析。

Serum brain-derived neurotrophic factor levels in type 2 diabetes mellitus patients and its association with cognitive impairment: A meta-analysis.

机构信息

Department of Medical Imaging Center, Gansu Provincial Maternal and Child Care Hospital (Gansu Provincial Central Hospital), Lanzhou, Gansu, China.

Department of Medical Imaging Center, Gansu Provincial Maternal and Child Care Hospital, Lanzhou, Gansu, China.

出版信息

PLoS One. 2024 Apr 22;19(4):e0297785. doi: 10.1371/journal.pone.0297785. eCollection 2024.

OBJECTIVE

To compare the serum levels of brain-derived neurotrophic factor (BDNF) in type 2 diabetes mellitus (T2DM) patients with healthy controls (HC) and evaluate the BDNF levels in T2DM patients with/without cognitive impairment.

METHODS

PubMed, EMBASE, and the Cochrane Library databases were searched for the published English literature on BDNF in T2DM patients from inception to December 2022. The BDNF data in the T2DM and HC groups were extracted, and the study quality was evaluated using the Agency for Healthcare Research and Quality. A meta-analysis of the pooled data was conducted using Review Manager 5.3 and Stata 12.0 software.

RESULTS

A total of 18 English articles fulfilled with inclusion criteria. The standard mean difference of the serum BDNF level was significantly lower in T2DM than that in the HC group (SMD: -2.04, z = 11.19, P <0.001). Besides, T2DM cognitive impairment group had a slightly lower serum BDNF level compared to the non-cognitive impairment group (SMD: -2.59, z = 1.87, P = 0.06).

CONCLUSION

BDNF might be involved in the neuropathophysiology of cerebral damage in T2DM, especially cognitive impairment in T2DM.

目的

比较 2 型糖尿病（T2DM）患者与健康对照者（HC）的血清脑源性神经营养因子（BDNF）水平，并评估 T2DM 患者中有无认知障碍时的 BDNF 水平。

方法

检索 PubMed、EMBASE 和 Cochrane 图书馆数据库中自成立至 2022 年 12 月发表的关于 T2DM 患者 BDNF 的英文文献。提取 T2DM 组和 HC 组的 BDNF 数据，并使用美国医疗保健研究与质量局评估研究质量。使用 Review Manager 5.3 和 Stata 12.0 软件对汇总数据进行荟萃分析。