Tahtakran Siroun A, Selleck Mark A J
Department of Cell and Neurobiology, University of Southern California, Keck School of Medicine, 1333 San Pablo Street, BMT 401, Los Angeles, CA 90089, USA.
Gene Expr Patterns. 2003 Aug;3(4):455-8. doi: 10.1016/s1567-133x(03)00065-6.
The transcription factor Ets-1 is expressed in many different migratory cell types, suggesting that it may play an important role in regulating motility. To determine whether its expression in the neural crest is consistent with such a function, we have performed a detailed analysis of its expression during early chick embryogenesis. Our results show that this transcription factor is up-regulated in the cranial neural folds and dorsal neural tube approximately 4-6 h prior to commencement of neural crest migration. c-Ets-1 continues to be expressed by migrating cranial neural crest cells and subsequently by some neural crest-derived tissues. In addition to neural crest, we find expression of c-Ets-1 in endothelial cells of blood vessels, in somitic and intermediate mesoderm, in limb buds and in the heart.
转录因子Ets-1在许多不同的迁移细胞类型中表达，这表明它可能在调节细胞运动性方面发挥重要作用。为了确定其在神经嵴中的表达是否与这种功能一致，我们对其在鸡胚早期发育过程中的表达进行了详细分析。我们的结果表明，在神经嵴开始迁移前约4-6小时，该转录因子在颅神经褶和背神经管中上调。c-Ets-1在迁移的颅神经嵴细胞中持续表达，随后在一些神经嵴衍生组织中表达。除了神经嵴，我们还在血管内皮细胞、体节和中间中胚层、肢芽和心脏中发现了c-Ets-1的表达。
