Committee on Development, Regeneration and Stem Cell Biology, The University of Chicago, Chicago, IL 60637, USA.
Department of Organismal Biology and Anatomy, The University of Chicago, Chicago, IL 60637, USA.
Development. 2020 Oct 26;147(20):dev193888. doi: 10.1242/dev.193888.
The neural crest is regionalized along the anteroposterior axis, as demonstrated by foundational lineage-tracing experiments that showed the restricted developmental potential of neural crest cells originating in the head. Here, we explore how recent studies of experimental embryology, genetic circuits and stem cell differentiation have shaped our understanding of the mechanisms that establish axial-specific populations of neural crest cells. Additionally, we evaluate how comparative, anatomical and genomic approaches have informed our current understanding of the evolution of the neural crest and its contribution to the vertebrate body.
神经嵴沿前后轴区域化，这一点通过基础的谱系追踪实验得到了证明，这些实验表明起源于头部的神经嵴细胞的发育潜力受到限制。在这里，我们探讨了实验胚胎学、遗传回路和干细胞分化的最新研究如何影响我们对建立神经嵴细胞轴向特异性群体的机制的理解。此外，我们还评估了比较、解剖和基因组方法如何为我们当前对神经嵴的进化及其对脊椎动物体的贡献的理解提供信息。
