Gimeno L, Brûlet P, Martínez S
Instituto de Neurosciencias, CSIC-UMH, Campus de San Juan, Apdo correos 18, 03550, Alicante, Spain.
Gene Expr Patterns. 2003 Aug;3(4):473-81. doi: 10.1016/s1567-133x(03)00059-0.
Fibroblast growth factor 15 (Fgf15) is a gene regulated by the expression of Otx2 in developing mouse brain (Proc Natl Acad Sci USA 97 (2000) 14388). Otx2 gene codes for a transcription factor and is fundamental for the regionalisation and development of the anterior neural plate and cephalic region of the vertebrate embryo (Development 124 (1997) 3639). In addition, the thalamic expression of Fgf15 has been recently reported under the control of Shh signalling gene, expressed in the diencephalic basal plate (Development 129 (2002) 4807). In the present work, we have analysed Fgf15 expression pattern during mouse neural development. Fgf15 appeared early in the developing neural epithelium, in domains where Fgf8 gene is also expressed and, at later stages, in specific groups of neural cells. Fgf8 is an important signalling protein with demonstrated morphogenetic activity in several embryonic regions. Fgf15 expression is localized, like Fgf8, in secondary neural tube organizers: the isthmic organizer (IsO) and the anterior neural ridge (ANR).
成纤维细胞生长因子15（Fgf15）是一个在发育中的小鼠大脑中受Otx2表达调控的基因（《美国国家科学院院刊》97 (2000) 14388）。Otx2基因编码一种转录因子，对脊椎动物胚胎前神经板和头部区域的区域化及发育至关重要（《发育》124 (1997) 3639）。此外，最近有报道称Fgf15在丘脑的表达受Shh信号基因的控制，该基因在间脑基板中表达（《发育》129 (2002) 4807）。在本研究中，我们分析了Fgf15在小鼠神经发育过程中的表达模式。Fgf15在发育中的神经上皮早期出现，在Fgf8基因也表达的区域，并且在后期，在特定的神经细胞群中表达。Fgf8是一种重要的信号蛋白，在几个胚胎区域具有已证实的形态发生活性。Fgf15的表达，与Fgf8一样，定位于次级神经管组织者：峡部组织者（IsO）和前神经嵴（ANR）。
