Gimeno L, Hashemi R, Brûlet P, Martínez S
Institut of Neurosciences, CSIC-UMH (Miguel Hernandez University), Alicante, Spain.
Brain Res Bull. 2002;57(3-4):297-9. doi: 10.1016/s0361-9230(01)00717-1.
The dynamic process of neural tube regionalization in vertebrates is regulated by the expression of developmental genes which appear in characteristic patterns at neuroepithelial transversal domains, which are called secondary organizers. The molecular code present in these neuroepithelial organizers controls the generation of morphogenetic signals that induce and maintain regional characteristics in the surrounding neuroepithelium. The product of the Fgf8 gene is a secreted protein that has been demonstrated to be the key molecule for the isthmic organizer and is also expressed in two other organizer regions: the zona limitans and the anterior neural ridge. Here we analyze the expression of Fgf15 at different stages of mouse development in relation to Fgf8 and Otx2 expression patterns.
脊椎动物神经管区域化的动态过程受发育基因表达的调控，这些基因以特征性模式出现在神经上皮横向区域，即所谓的次级组织者。这些神经上皮组织者中存在的分子编码控制形态发生信号的产生，这些信号诱导并维持周围神经上皮的区域特征。Fgf8基因的产物是一种分泌蛋白，已被证明是峡部组织者的关键分子，并且还在其他两个组织者区域表达：界带和前神经嵴。在这里，我们分析了小鼠发育不同阶段Fgf15的表达与Fgf8和Otx2表达模式的关系。
