Richter W O
Institut für Fettstoffwechsel und Hämorheologie, Blumenstr. 6, D-86949 Windach, Germany.
Eur J Med Res. 2003 Aug 20;8(8):332-6.
An increase in the uptake of long-chain Omega-3 fatty acids from fish with the diet or as ethyl esters resulted in a decreased risk for cardiac death. As mechanism for this rapidly occurring benefit (within 90 days of treatment significantly different to placebo) antiarrhythmic effects at cardiac myocytes and plaques stabilization can be discussed. The results of the GISSI Prevenzione Trial show that 175 patients have to be treated for one year to avoid one death. Regarding other available data for secondary prevention this efficacy is superior to pravastatin and at the same level as simvastatin or aspirin. Only beta-blocking agents are superior, but it is of interest that long-chain Omega-3 fatty acids from fish display their beneficial effects even in patients already treated with beta-blockers. As the intake of 0.85 g of long-chain Omega-3 fatty acids from fish per day can be regarded as save and the positive effect on total mortality occurs already after 90 days their regular use is a promising additional measure for secondary prevention.
通过饮食摄入或作为乙酯形式摄入的鱼类中的长链Omega-3脂肪酸增加，会降低心脏性死亡风险。对于这种迅速出现的益处（治疗90天内与安慰剂相比有显著差异）的机制，可以探讨心肌细胞的抗心律失常作用和斑块稳定作用。GISSI预防试验的结果表明，必须治疗175名患者一年才能避免1例死亡。就二级预防的其他现有数据而言，这种疗效优于普伐他汀，与辛伐他汀或阿司匹林处于同一水平。只有β受体阻滞剂更优，但有趣的是，鱼类中的长链Omega-3脂肪酸即使在已经接受β受体阻滞剂治疗的患者中也能发挥有益作用。由于每天从鱼类中摄入0.85克长链Omega-3脂肪酸可被视为安全的，并且对总死亡率的积极影响在90天后就已出现，因此定期使用它们是二级预防中一种有前景的额外措施。
