Harris William S, Von Schacky Clemens
Lipid and Diabetes Research Center, Mid America Heart Institute of Saint Luke's Hospital, University of Missouri-KC School of Medicine, Kansas City, MO 64111, USA.
Prev Med. 2004 Jul;39(1):212-20. doi: 10.1016/j.ypmed.2004.02.030.
Low intakes or blood levels of eicosapentaenoic and docosahexaenoic acids (EPA + DHA) are independently associated with increased risk of death from coronary heart disease (CHD). In randomized secondary prevention trials, fish or fish oil have been demonstrated to reduce total and CHD mortality at intakes of about 1 g/day. Red blood cell (RBC) fatty acid (FA) composition reflects long-term intake of EPA + DHA. We propose that the RBC EPA + DHA (hereafter called the Omega-3 Index) be considered a new risk factor for death from CHD.
We conducted clinical and laboratory experiments to generate data necessary for the validation of the Omega-3 Index as a CHD risk predictor. The relationship between this putative marker and risk for CHD death, especially sudden cardiac death (SCD), was then evaluated in several published primary and secondary prevention studies.
The Omega-3 Index was inversely associated with risk for CHD mortality. An Omega-3 Index of > or = 8% was associated with the greatest cardioprotection, whereas an index of < or = 4% was associated with the least.
The Omega-3 Index may represent a novel, physiologically relevant, easily modified, independent, and graded risk factor for death from CHD that could have significant clinical utility.
二十碳五烯酸和二十二碳六烯酸（EPA + DHA）的低摄入量或血液水平与冠心病（CHD）死亡风险增加独立相关。在随机二级预防试验中，已证明鱼类或鱼油在每日摄入量约1克时可降低总死亡率和冠心病死亡率。红细胞（RBC）脂肪酸（FA）组成反映了EPA + DHA的长期摄入量。我们建议将红细胞EPA + DHA（以下称为Omega-3指数）视为冠心病死亡的一个新的风险因素。
我们进行了临床和实验室实验，以生成验证Omega-3指数作为冠心病风险预测指标所需的数据。然后在几项已发表的一级和二级预防研究中评估了这个假定标志物与冠心病死亡风险，尤其是心源性猝死（SCD）风险之间的关系。
Omega-3指数与冠心病死亡率风险呈负相关。Omega-3指数≥8%与最大的心脏保护作用相关，而指数≤4%与最小的保护作用相关。
Omega-3指数可能代表一种新的、生理相关的、易于改变的、独立的且分级的冠心病死亡风险因素，可能具有显著的临床效用。
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