大学生群体中血清素转运体启动子多态性与饮酒行为差异
Serotonin transporter promoter polymorphism and differences in alcohol consumption behaviour in a college student population.
作者信息
Herman Aryeh I, Philbeck John W, Vasilopoulos Nicholas L, Depetrillo Paolo B
机构信息
Unit of Clinical and Biochemical Pharmacology, Laboratory of Clinical Studies, Intramural Research Program, National Institutes on Alcohol Abuse and Alcoholism, NIH 10/3C103, 10 Center Drive, MSC 1256, Bethesda, MD 20892-1256, USA.
出版信息
Alcohol Alcohol. 2003 Sep-Oct;38(5):446-9. doi: 10.1093/alcalc/agg110.
AIMS AND METHODS
In the present study, differences in alcohol consumption behaviour associated with the presence of the short variant (S) of the serotonin transporter promoter polymorphism (5-HTTLPR) was investigated in a Caucasian subset (n = 204) of 268 college students.
RESULTS
Students who were homozygous for the S allele were more likely to engage in binge-drinking behaviour, drank more alcohol per occasion, and reported drinking to get drunk more often.
CONCLUSIONS
In this Caucasian sample, the 5-HTTLPR strongly influences alcohol consumption in late pubescence.
目的与方法
在本研究中，我们在268名大学生的白种人亚组（n = 204）中，研究了与血清素转运体启动子多态性（5-HTTLPR）短变体（S）的存在相关的饮酒行为差异。
结果
S等位基因纯合的学生更有可能出现暴饮行为，每次饮酒量更多，且报告称更常为了喝醉而饮酒。
结论
在这个白种人样本中，5-HTTLPR对青春期后期的酒精消费有强烈影响。
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