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一种艾滋病疫苗在猕猴艾滋病模型中的保护效力：先用单一DNA疫苗初免，再用重组复制缺陷型仙台病毒载体进行单次加强免疫。

Protective efficacy of an AIDS vaccine, a single DNA priming followed by a single booster with a recombinant replication-defective Sendai virus vector, in a macaque AIDS model.

作者信息

Takeda Akiko, Igarashi Hiroko, Nakamura Hiromi, Kano Munehide, Iida Akihiro, Hirata Takahiro, Hasegawa Mamoru, Nagai Yoshiyuki, Matano Tetsuro

机构信息

Department of Microbiology, Graduate School of Medicine, The University of Tokyo, Tokyo 113-0033, Japan.

出版信息

J Virol. 2003 Sep;77(17):9710-5. doi: 10.1128/jvi.77.17.9710-9715.2003.

DOI:10.1128/jvi.77.17.9710-9715.2003
PMID:12915583
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC187428/
Abstract

We previously demonstrated the excellent protective efficacy of DNA priming followed by Gag-expressing Sendai virus (SeV) boosting (DNA prime/SeV-Gag boost vaccine) against a pathogenic simian-human immunodeficiency virus (SHIV89.6PD) infection in macaques. Here we show that we established a practical, safer AIDS vaccine protocol, a single DNA priming followed by a single booster with a recently developed replication-defective F deletion SeV-expressing Gag, and show its protective efficacy against SHIV89.6PD infections.

摘要

我们之前证明了先用DNA启动，再用表达Gag的仙台病毒（SeV）加强免疫（DNA启动/SeV-Gag加强疫苗），对猕猴感染致病性猿猴-人类免疫缺陷病毒（SHIV89.6PD）具有出色的保护效果。在此我们表明，我们建立了一种实用、更安全的艾滋病疫苗方案，即单次DNA启动，随后用最近开发的表达Gag的复制缺陷型F缺失SeV进行单次加强免疫，并展示了其对SHIV89.6PD感染的保护效果。

相似文献

1
Protective efficacy of an AIDS vaccine, a single DNA priming followed by a single booster with a recombinant replication-defective Sendai virus vector, in a macaque AIDS model.一种艾滋病疫苗在猕猴艾滋病模型中的保护效力：先用单一DNA疫苗初免，再用重组复制缺陷型仙台病毒载体进行单次加强免疫。
J Virol. 2003 Sep;77(17):9710-5. doi: 10.1128/jvi.77.17.9710-9715.2003.
2
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本文引用的文献

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Nature. 2002 Jan 17;415(6869):331-5. doi: 10.1038/415331a.
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Control of a mucosal challenge and prevention of AIDS by a multiprotein DNA/MVA vaccine.一种多蛋白DNA/MVA疫苗对黏膜攻击的控制及艾滋病的预防
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Elicitation of protective immunity against simian immunodeficiency virus infection by a recombinant Sendai virus expressing the Gag protein.表达Gag蛋白的重组仙台病毒引发针对猿猴免疫缺陷病毒感染的保护性免疫
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Induction of protective immunity against pathogenic simian immunodeficiency virus by a foreign receptor-dependent replication of an engineered avirulent virus.通过工程化无毒病毒的外源受体依赖性复制诱导针对致病性猿猴免疫缺陷病毒的保护性免疫。
Vaccine. 2000 Aug 1;18(28):3310-8. doi: 10.1016/s0264-410x(00)00122-5.
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A cytoplasmic RNA vector derived from nontransmissible Sendai virus with efficient gene transfer and expression.一种源自非传染性仙台病毒的细胞质RNA载体，具有高效的基因转移和表达能力。
J Virol. 2000 Jul;74(14):6564-9. doi: 10.1128/jvi.74.14.6564-6569.2000.