Bunt Joy C, Salbe Arline D, Tschöp Matthias H, DelParigi Angelo, Daychild Pamela, Tataranni P Antonio
Clinical Diabetes and Nutrition Section, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Phoenix, Arizona 85016, USA.
J Clin Endocrinol Metab. 2003 Aug;88(8):3756-61. doi: 10.1210/jc.2003-030227.
Ghrelin, a recently discovered GH secretagogue with orexigenic effects, is proposed to be a regulator of energy balance. To test whether fasting plasma ghrelin concentrations predict future gain in body weight or adiposity, we measured weight, height, body mass index (BMI), percentage of body fat (by dual energy x-ray absorptiometry), and fasting plasma concentrations of ghrelin, insulin, and glucose in 10-yr-old Pima Indians (n = 40; 13 males and 27 females) and subsequent weight, height, and BMI 1.7 +/- 0.6 yr later. At baseline, the fasting plasma ghrelin concentration was negatively associated with height (r = -0.52; P = 0.0006), weight, (r = -0.37; P = 0.02), percentage of body fat (r = -0.33, P = 0.04), and fasting plasma insulin concentration (r = -0.41; P = 0.01). In multiple regression models adjusting for gender and fasting plasma insulin, the fasting plasma ghrelin concentration was an independent determinant of height (beta = -13.9; P = 0.02), but not weight or BMI. Prospectively, the baseline fasting plasma ghrelin concentration was not an independent determinant of the relative rate of increase in weight, height, or adiposity. In conclusion, the fasting plasma ghrelin concentration was lower in taller and fatter Pima Indian children, but did not independently predict baseline weight, adiposity, or future growth rates. These data do not support a direct relationship between the fasting plasma ghrelin concentration and subsequent relative changes in height or weight in growing children.
胃饥饿素是一种最近发现的具有促食欲作用的生长激素促分泌素，被认为是能量平衡的调节因子。为了测试空腹血浆胃饥饿素浓度是否能预测未来体重或肥胖程度的增加，我们测量了40名10岁皮马印第安人（13名男性和27名女性）的体重、身高、体重指数（BMI）、体脂百分比（通过双能X线吸收法测量）以及空腹血浆中胃饥饿素、胰岛素和葡萄糖的浓度，并在1.7±0.6年后再次测量了他们的体重、身高和BMI。在基线时，空腹血浆胃饥饿素浓度与身高呈负相关（r = -0.52；P = 0.0006）、体重（r = -0.37；P = 0.02）、体脂百分比（r = -0.33，P = 0.04）以及空腹血浆胰岛素浓度（r = -0.41；P = 0.01）。在调整了性别和空腹血浆胰岛素的多元回归模型中，空腹血浆胃饥饿素浓度是身高的独立决定因素（β = -13.9；P = 0.02），但不是体重或BMI的独立决定因素。前瞻性地看，基线空腹血浆胃饥饿素浓度不是体重、身高或肥胖程度相对增加率的独立决定因素。总之，较高和较胖的皮马印第安儿童空腹血浆胃饥饿素浓度较低，但不能独立预测基线体重、肥胖程度或未来生长速率。这些数据不支持空腹血浆胃饥饿素浓度与成长中儿童身高或体重随后的相对变化之间存在直接关系。
