Pomerants T, Tillmann V, Jürimäe J, Jürimäe T
Sport Pedagogy, Center of Behavioral and Health Sciences, University of Tartu, Jakobi 5, 51014 Tartu, Estonia.
J Endocrinol Invest. 2006 Dec;29(11):962-7. doi: 10.1007/BF03349208.
The aim of this study was to investigate the relationships between fasting serum ghrelin concentration, anthropometrical and body composition data in boys at different pubertal stages. Sixty healthy non-obese Estonian schoolboys (10 to 18 yr) were divided into 3 groups based on Tanner classification--group I was prepubertal, group II included stages 2 and 3, and group III stages 4 and 5. Additionally, we analyzed subjects as a total group. Fasting ghrelin, leptin, testosterone, insulin and glucose were collected between 08:00 and 10:00 h. Body fat % and lean body mass (LBM) were determined by dual-energy X-ray absorptiometry. Fasting ghrelin decreased, while leptin and insulin did not change and testosterone increased during puberty. There was a negative correlation between serum ghrelin and testosterone concentrations in group II (r=-0.51, p<0.05) and in the total group (r=-0.59, p<0.001). Ghrelin was also related to body height, body mass and LBM in group II and total group also with body mass index in total group. Stepwise multiple regression analysis showed that body height from auxological, LBM from body composition and testosterone from biochemical data explained 38.1, 41.7 and 33.7% of the ghrelin variance in the total group, respectively. In conclusion, body height, LBM and serum testosterone are the major determinants of serum ghrelin among parameters studied. Negative correlation between serum ghrelin and testosterone concentrations indicates that ghrelin may also have a role in male pubertal development.
本研究旨在调查不同青春期阶段男孩的空腹血清胃饥饿素浓度、人体测量学数据和身体成分之间的关系。60名健康非肥胖的爱沙尼亚男学生（10至18岁）根据坦纳分类法分为3组——I组为青春期前，II组包括2期和3期，III组包括4期和5期。此外，我们将所有受试者作为一个整体组进行分析。在08:00至10:00之间采集空腹胃饥饿素、瘦素、睾酮、胰岛素和葡萄糖。通过双能X线吸收法测定体脂百分比和瘦体重（LBM）。青春期期间，空腹胃饥饿素水平下降，而瘦素和胰岛素水平无变化，睾酮水平升高。II组（r=-0.51，p<0.05）和整体组（r=-0.59，p<0.001）的血清胃饥饿素与睾酮浓度之间呈负相关。II组和整体组中，胃饥饿素还与身高、体重和LBM相关，整体组中还与体重指数相关。逐步多元回归分析表明，来自体格检查的身高、来自身体成分的LBM和来自生化数据的睾酮分别解释了整体组中胃饥饿素变异的38.1%、41.7%和33.7%。总之，在所研究的参数中，身高、LBM和血清睾酮是血清胃饥饿素的主要决定因素。血清胃饥饿素与睾酮浓度之间的负相关表明，胃饥饿素可能在男性青春期发育中也发挥作用。
