Garcés Carmen, Benavente Mercedes, Cano Beatriz, Viturro Enrique, Ortega Henar, Horcajada Cristina, De Oya Manuel
Unidad de Lípidos, Fundación Jiménez Díaz, Universidad Autónoma de Madrid.
J Clin Endocrinol Metab. 2003 Aug;88(8):3997-4000. doi: 10.1210/jc.2003-030459.
Gender differences in the apolipoprotein (apo) E genotype effect on plasma lipid levels reported in adults have also been found in pre-pubertal children. In adults, the difference seems to be due to the influence of sexual hormones. The reason why this difference exits between pre-pubertal girls and boys, for whom those sexual hormones are not different, is unclear. However, there is an important difference in Dehydroepiandrosterone-sulfate (DHEA-S) levels between pre-pubertal boys and girls. To evaluate the influence of DHEA-S on apo E genetic determinants of plasma lipids levels in pre-pubertal children we measured plasma DHEA-S in 1045 healthy children (534 males and 511 females) 6 to 8 years old in which a different apoE influence on lipid levels had been reported between girls and boys. Our observations demonstrate that the extent of the lipid increasing or decreasing effects associated with each allele were modulated by DHEA-S. DHEA-S increases the hypolipemic effect of the epsilon2 allele and decreases the hyperlipemic effect of the epsilon4 allele. In conclusion, the interaction of apo E genotype and DHEA-S may represent a critical determinant of TC, LDL-C and apo B levels in children at the prepuberal age.
在青春期前儿童中也发现了载脂蛋白（apo）E基因分型对血浆脂质水平影响的性别差异。在成年人中，这种差异似乎是由于性激素的影响。对于青春期前的女孩和男孩来说，性激素并无差异，但他们之间存在这种差异的原因尚不清楚。然而，青春期前男孩和女孩的硫酸脱氢表雄酮（DHEA-S）水平存在重要差异。为了评估DHEA-S对青春期前儿童血浆脂质水平的apo E基因决定因素的影响，我们测量了1045名6至8岁健康儿童（534名男性和511名女性）的血浆DHEA-S，在这些儿童中，女孩和男孩的apoE对脂质水平的影响有所不同。我们的观察结果表明，与每个等位基因相关的脂质增加或减少效应的程度受DHEA-S调节。DHEA-S增强了ε2等位基因的降血脂作用，并降低了ε4等位基因的升血脂作用。总之，apo E基因分型与DHEA-S的相互作用可能是青春期前儿童总胆固醇（TC）、低密度脂蛋白胆固醇（LDL-C）和载脂蛋白B水平的关键决定因素。
