Garcés Carmen, Benavente Mercedes, Ortega Henar, Rubio Rafael, Lasunción Miguel Angel, Rodríguez Artalejo Fernando, Fernandez Pardo Jacinto, de Oya Manuel
Unidad de Lípidos, Fundación Jiménez Díaz, Universidad Autónoma de Madrid, Avda. Reyes Católicos, 2 28040 Madrid, Spain.
Pediatr Res. 2002 Dec;52(6):873-8. doi: 10.1203/00006450-200212000-00011.
To evaluate the influence of birth weight on apolipoprotein (apo) E genetic determinants of plasma lipids levels in prepubertal children we studied 933 healthy children (491 males and 442 females) 6 to 8 years old (mean age of 6.7 y), whose weight was recorded at birth. Plasma lipid and apolipoprotein concentrations and apo E genotypes were determined. We observed a greater effect of the apo E polymorphism on total cholesterol (TC), LDL-cholesterol (LDL-C) and especially apo B levels in children with birth weight in the lower tertile compared with those with birth weights in higher tertiles. Taking the epsilon3 allele homozygosity as reference, in boys with birth weights in the low tertile the overall lowering effect of the epsilon2 allele on TC, LDL-C and apo B was greater (10.5% (p < 0.01), 20.2% (p < 0.01) and 18.8% (p < 0.01), respectively) than in those in the highest tertile (5.6% on TC, 10.3% on LDL-C and 12.6% (p < 0.01) on apo B). A similar trend in this effect between tertiles of birth weight was also observed in girls. For both sexes, linear regression analysis demonstrates a positive and significant interaction between birth weight and epsilon2, which may explain the fact that the decrease in TC, LDL-C and apo B associated with the epsilon2 allele is more marked the lower the birth weight. Taking into account the prevalence of apo E polymorphism, and that appears to be the main genetic factor affecting plasma lipids, the interaction of apo E genotype and birth weight could be an important determinant of TC, LDL-C and apo B levels, and, as a consequence, of atherosclerosis.
为评估出生体重对青春期前儿童血脂水平载脂蛋白（apo）E基因决定因素的影响，我们研究了933名6至8岁（平均年龄6.7岁）的健康儿童（491名男性和442名女性），他们出生时的体重有记录。测定了血脂和载脂蛋白浓度以及apo E基因型。我们观察到，与出生体重处于较高三分位数的儿童相比，出生体重处于较低三分位数的儿童中，apo E多态性对总胆固醇（TC）、低密度脂蛋白胆固醇（LDL-C）尤其是apo B水平的影响更大。以ε3等位基因纯合子为参照，出生体重处于低三分位数的男孩中，ε2等位基因对TC、LDL-C和apo B的总体降低作用（分别为10.5%（p<0.01）、20.2%（p<0.01）和18.8%（p<0.01））比出生体重处于最高三分位数的男孩（对TC为5.6%，对LDL-C为10.3%，对apo B为12.6%（p<0.01））更大。在女孩中也观察到出生体重三分位数之间这种效应的类似趋势。对于两性，线性回归分析表明出生体重与ε2之间存在正向且显著的相互作用，这可能解释了与ε2等位基因相关的TC、LDL-C和apo B的降低在出生体重越低时越明显这一事实。考虑到apo E多态性的患病率，且其似乎是影响血脂的主要遗传因素，apo E基因型与出生体重的相互作用可能是TC、LDL-C和apo B水平以及动脉粥样硬化的一个重要决定因素。
