Pahwa Punam, McDuffie Helen H, Dosman James A, Robson Diane, McLaughlin John R, Spinelli John J, Fincham Shirley
Institute of Agricultural Rural and Environmental Health, Saskatchewan Cancer Agency, Saskatoon SK S7N 0W8, Canada.
J Occup Environ Med. 2003 Aug;45(8):857-68. doi: 10.1097/01.jom.0000083033.56116.c1.
Exposures to farm animals has been associated with certain rare cancers. Simultaneously, using the same methodology and control group, we conducted a six-province incident, population-based study of Hodgkin's disease (HD), multiple myeloma (MM), and soft tissue sarcoma (STS). Farm residence or work was reported by 38% (n = 119) of HD, 45% (n = 178) of MM, 43% (n = 156) of STS cases and 45% (n = 673) of controls. We conducted conditional logistic regression analyses and report odds ratios (OR(adj)) and 95% confidence intervals. After adjustment for covariates, exposure to farm animals had minimal effect on risk. The independent risk factors after adjustment for covariates were a family history of cancer (MM, STS), occupational uranium exposure (HD), professional driving (MM), and personal previous cancer (MM) or shingles (HD, MM).
接触农场动物与某些罕见癌症有关。同时，我们采用相同的方法和对照组，在六个省份开展了一项基于人群的霍奇金淋巴瘤（HD）、多发性骨髓瘤（MM）和软组织肉瘤（STS）发病情况研究。HD患者中有38%（n = 119）、MM患者中有45%（n = 178）、STS患者中有43%（n = 156）以及对照组中有45%（n = 673）报告有农场居住或工作经历。我们进行了条件逻辑回归分析，并报告了比值比（OR(adj)）和95%置信区间。在对协变量进行调整后，接触农场动物对风险的影响极小。调整协变量后的独立风险因素包括癌症家族史（MM、STS）、职业性铀暴露（HD）、职业驾驶（MM）以及个人既往癌症史（MM）或带状疱疹病史（HD、MM）。
