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意大利血液淋巴系统恶性肿瘤多中心病例对照研究。

Italian multicentre case-control study of hematolymphopoietic malignancies.

作者信息

Vineis P, Seniori Costantini A

机构信息

Dipartimento di Scienze Biomediche e Oncologia Umana, Ospedale Maggiore, Torino.

出版信息

Med Lav. 1990 Nov-Dec;81(6):506-12.

PMID:2100766
Abstract

Exposures to organic solvents (including benzene), ionizing radiation and low frequency electromagnetic fields have been suggested as risk factors for leukemias in adults. Exposure to herbicides of the phenoxyacid variety (2, 4, 5-T; 2, 4-D) has been reported to be associated with an increased risk of non-Hodgkin's lymphomas. In addition several studies have suggested that agricultural workers have an excess risk of hematolymphopoietic malignancies, although no specific agent has yet been identified. Italy is particularly attractive for investigating further these associations, because: a) there is a high prevalence of exposure to solvents in industrial areas (estimated to be 10-16% in the province of Torino, Varese and Florence), and a high prevalence of exposure to herbicides (including phenoxyacides) in agricultural areas; b) there is also considerable extra-occupational exposure to solvents and pesticides; c) competent groups of hematologists exist in several towns, using advanced diagnostic techniques including cytogenetics. We propose therefore to conduct a multicenter population-based case-control study in 11 italian areas, chosen on the basis of a high exposure prevalence. In three years, we intend to interview approximately 1100 cases of leukemia, 1900 cases of lymphoma (Hodgkin and non-Hodgkin) and 400 cases of myeloma; 1900 randomly selected individuals, residents of the same areas, will serve as a population control group. Cases will be all those occurring in the study period among residents of the 11 areas, newly diagnosed. Particular care will be dedicated to diagnostic aspects, including B- and T- cell characterization. Cases and controls will be blindly interviewed by trained personnel.(ABSTRACT TRUNCATED AT 250 WORDS)

摘要

有机溶剂(包括苯)、电离辐射和低频电磁场暴露已被认为是成人白血病的危险因素。据报道,接触苯氧基酸类除草剂(2,4,5-T;2,4-D)会增加患非霍奇金淋巴瘤的风险。此外,多项研究表明,农业工人患血液淋巴系统恶性肿瘤的风险较高,尽管尚未确定具体病因。意大利对于进一步研究这些关联特别具有吸引力,原因如下:a)工业区有机溶剂暴露率很高(据估计,在都灵、瓦雷泽和佛罗伦萨省为10%-16%),农业区除草剂(包括苯氧基酸)暴露率也很高;b)在职业之外,也有大量有机溶剂和杀虫剂暴露;c)几个城镇有专业的血液学团队,使用包括细胞遗传学在内的先进诊断技术。因此,我们建议在11个意大利地区开展一项基于人群的多中心病例对照研究,这些地区是根据高暴露率选定的。在三年内,我们打算访谈约1100例白血病患者、1900例淋巴瘤(霍奇金淋巴瘤和非霍奇金淋巴瘤)患者以及400例骨髓瘤患者;1900名从同一地区随机选取的居民将作为人群对照组。病例将包括研究期间在11个地区新诊断的所有居民病例。将特别关注诊断方面,包括B细胞和T细胞特征。病例和对照将由经过培训的人员进行盲法访谈。(摘要截选至250词)

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