Hoar S K, Blair A, Holmes F F, Boysen C D, Robel R J, Hoover R, Fraumeni J F
JAMA. 1986 Sep 5;256(9):1141-7.
A population-based case-control study of soft-tissue sarcoma (STS), Hodgkin's disease (HD), and non-Hodgkin's lymphoma (NHL) in Kansas found farm herbicide use to be associated with NHL (odds ratio [OR], 1.6; 95% confidence interval [CI], 0.9, 2.6). Relative risk of NHL increased significantly with number of days of herbicide exposure per year and latency. Men exposed to herbicides more than 20 days per year had a sixfold increased risk of NHL (OR, 6.0; 95% CI, 1.9, 19.5) relative to nonfarmers. Frequent users who mixed or applied the herbicides themselves had an OR of 8.0 (95% CI, 2.3, 27.9) for NHL. Excesses were associated with use of phenoxyacetic acid herbicides, specifically 2,4-dichlorophenoxyacetic acid. Neither STS nor HD was associated with pesticide exposure. This study confirms the reports from Sweden and several US states that NHL is associated with farm herbicide use, especially phenoxyacetic acids. It does not confirm the case-control studies or the cohort studies of pesticide manufacturers and Vietnam veterans linking herbicides to STS or HD.
堪萨斯州一项基于人群的软组织肉瘤（STS）、霍奇金淋巴瘤（HD）和非霍奇金淋巴瘤（NHL）病例对照研究发现，使用农用除草剂与NHL有关（优势比[OR]为1.6；95%置信区间[CI]为0.9至2.6）。NHL的相对风险随每年接触除草剂的天数和潜伏期显著增加。每年接触除草剂超过20天的男性患NHL的风险比非农民高6倍（OR为6.0；95%CI为1.9至19.5）。自行混合或施用除草剂的频繁使用者患NHL的OR为8.0（95%CI为2.3至27.9）。过量接触与苯氧基乙酸除草剂的使用有关，特别是2,4-二氯苯氧基乙酸。STS和HD均与农药接触无关。这项研究证实了瑞典和美国几个州的报告，即NHL与农用除草剂的使用有关，尤其是苯氧基乙酸。它没有证实农药制造商和越南退伍军人将除草剂与STS或HD联系起来的病例对照研究或队列研究。
