Borelli A, Leite M O, Correa P H, Jorgetti V, Marcondes J A, Batalha J R, Cintra A B, Wajchenberg B L
Endocrine Service, 1st Medical Clinics Hospital das Clínicas, University of São Paulo, Brazil.
J Endocrinol Invest. 1992 Dec;15(11):783-7. doi: 10.1007/BF03348804.
Bone involvement is a common finding in Cushing's syndrome. The actions of corticosteroids on bone have been studied quite intensively but only a few studies of bone histomorphometry in this syndrome have been published. In this paper we present histomorphometric measurements of bone activity in 7 patients with a postoperative reevaluation in two. The results show irregular alterations on histomorphometric parameters with an increased bone resorption and decreased bone formation rate. After surgery the abnormalities changed towards normal.
骨骼受累是库欣综合征的常见表现。皮质类固醇对骨骼的作用已得到深入研究，但关于该综合征骨组织形态计量学的研究仅有少数发表。在本文中，我们展示了7例患者的骨组织形态计量学测量结果，并对其中2例进行了术后重新评估。结果显示，骨组织形态计量学参数出现不规则改变，骨吸收增加，骨形成率降低。术后这些异常情况趋于正常。
