Insulin resistance due to mutations of the insulin receptor gene: an overview.

作者信息

Accili D, Cama A, Barbetti F, Kadowaki H, Kadowaki T, Taylor S I

机构信息

Diabetes Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland 20892.

出版信息

J Endocrinol Invest. 1992 Dec;15(11):857-64. doi: 10.1007/BF03348820.

DOI:10.1007/BF03348820

PMID:1291599

Abstract

摘要

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Am J Clin Pathol. 1956 Mar;26(3):283-90. doi: 10.1093/ajcp/26.3.283.

Qualitative abnormalities in insulin binding in a patient with extreme insulin resistance: decreased sensitivity to alterations in temperature and pH.一名极端胰岛素抵抗患者胰岛素结合的定性异常：对温度和pH值变化的敏感性降低。

Proc Natl Acad Sci U S A. 1981 Nov;78(11):7157-61. doi: 10.1073/pnas.78.11.7157.

A case of leprechaunism with severe hyperinsulinemia.一例伴有严重高胰岛素血症的妖精貌综合征。

Am J Dis Child. 1980 Feb;134(2):170-5. doi: 10.1001/archpedi.1980.02130140044014.

Gene for human insulin receptor: localization to site on chromosome 19 involved in pre-B-cell leukemia.人胰岛素受体基因：定位于19号染色体上与前B细胞白血病相关的位点。

Science. 1985 May 10;228(4700):728-31. doi: 10.1126/science.3873110.

A mutant insulin receptor with defective tyrosine kinase displays no biologic activity and does not undergo endocytosis.具有缺陷型酪氨酸激酶的突变胰岛素受体不显示生物活性，也不发生内吞作用。

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Proc Natl Acad Sci U S A. 1989 Jan;86(1):114-8. doi: 10.1073/pnas.86.1.114.

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